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Titolo:
Aerobic capacity of frog skeletal muscle during hibernation
Autore:
St-Pierre, J; Boutilier, RG;
Indirizzi:
Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England Univ Cambridge Cambridge England CB2 3EJ ool, Cambridge CB2 3EJ, England
Titolo Testata:
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
fascicolo: 3, volume: 74, anno: 2001,
pagine: 390 - 397
SICI:
1522-2152(200105/06)74:3<390:ACOFSM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC DEPRESSION; NEOBATRACHUS-PELOBATOIDES; PROTEIN-SYNTHESIS; GENE-EXPRESSION; ENZYME BINDING; OTALA-LACTEA; LAND SNAIL; ESTIVATION; ANOXIA; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: St-Pierre, J MRC, Dunn Human Nutr Unit, Hills Rd, Cambridge CB2 2XY, England MRC Hills Rd Cambridge England CB2 2XY idge CB2 2XY, England
Citazione:
J. St-Pierre e R.G. Boutilier, "Aerobic capacity of frog skeletal muscle during hibernation", PHYSIOL B Z, 74(3), 2001, pp. 390-397

Abstract

Frogs submerged at 3 degreesC in hypoxic water (Po-2 = 60 mmHg) depress their metabolic rate to 25% of that seen in control animals with access to air. The hypometabolic state of the skeletal muscle in such cold-submerged frogs is thought to be the most important contributor to the overall metabolic depression. The aim of this study was to determine whether the aerobic capacity of frog skeletal muscle became altered during 1-4 mo of hibernation to match the reduction in adenosine triphosphate (ATP) demand. To this end,the activities of key mitochondrial enzymes were measured in the skeletal muscle and in isolated mitochondria of frogs at different stages during hibernation. We also measured the activity of lactate dehydrogenase (LDH) as an indicator of glycolytic capacity. The activities of cytochrome c oxidase,citrate synthase, and LDH were significantly lower in frog skeletal muscleafter 4 mo of hibernation compared with control conditions. The reduction in skeletal muscle aerobic capacity is apparently due to changes in the intrinsic properties of the mitochondria. Overall, these results indicate an important reorganisation of ATP-producing pathways during long-term metabolic depression to match the lowered ATP demand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:22:01