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Titolo:
Age-related protective immunity after vaccination with Haemonchus contortus excretory/secretory proteins
Autore:
Vervelde, L; Kooyman, FNJ; Van Leeuwen, MAW; Schallig, HDFH; Mackellar, A; Huntley, JF; Cornelissen, AWCA;
Indirizzi:
Univ Utrecht, Inst Infect Dis & Immunol, Dept Parasitol & Trop Vet Med, NL-3508 TD Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TD3508 TD Utrecht, Netherlands Moredun Res Inst, Int Res Ctr, Penicuik, Midlothian, Scotland Moredun Res Inst Penicuik Midlothian Scotland cuik, Midlothian, Scotland
Titolo Testata:
PARASITE IMMUNOLOGY
fascicolo: 8, volume: 23, anno: 2001,
pagine: 419 - 426
SICI:
0141-9838(200108)23:8<419:APIAVW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICHOSTRONGYLUS-COLUBRIFORMIS; ADULT PARASITE; LAMBS; SHEEP; RUMINANTS; MEMBRANE; IMMUNIZATION; HEMONCHOSIS; INFECTION; RESPONSES;
Keywords:
Haemonchus contortus; excretory; secretory proteins; vaccination; immune response; age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Vervelde, L Univ Utrecht, Inst Infect Dis & Immunol, Dept Parasitol & TropVet Med, POB 80-165, NL-3508 TD Utrecht, Netherlands Univ Utrecht POB 80-165 Utrecht Netherlands NL-3508 TD rlands
Citazione:
L. Vervelde et al., "Age-related protective immunity after vaccination with Haemonchus contortus excretory/secretory proteins", PARASITE IM, 23(8), 2001, pp. 419-426

Abstract

Protection against an experimental challenge infection by immunization with excretory/secretory products (ES) from Haemonchus contortus, containing predominantly proteins of 15 and 24 kDa, depends on the age of the sheep. Vaccinated sheep 9 and 6 months of age had reduced final worm burdens of 82 and 77, respectively. No reduction in worm burden was found in 3-month-old lambs. Nine-month-old sheep had significantly higher ES-specific serum immunoglobulin (Ig)G1 and IgA during immunizations and after challenge infectionthan 3-month-old lambs. There was no correlation within the 9-month-old sheep between ES-specific IgA or IgG1 levels and protection, measured as wormburden. However, when the different age groups were combined, negative correlations between percentage protection and ES-specific IgA and IgG1 levelsafter challenge were found. At the end of the experiment, peripheral bloodeosinophils and mast cell counts in abomasal tissue were also significantly higher in the vaccinated and challenged 9-month-old sheep than in the vaccinated and challenged 3-month-old or than in the 9-month-old sheep with challenge, but without vaccination. The responses measured in young lambs were similar to the responses in sheep, but the height of these responses was in general of a lower magnitude.

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Documento generato il 19/09/20 alle ore 21:26:03