Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Birthweight, vitamin D receptor genotype and the programming of osteoporosis
Autore:
Dennison, EM; Arden, NK; Keen, RW; Syddall, H; Day, INM; Spector, TD; Cooper, C;
Indirizzi:
Univ Southampton, MRC, Environm Epidemiol Unit, Southampton Gen Hosp, Southampton, Hants, England Univ Southampton Southampton Hants England , Southampton, Hants, England St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London, England St ThomasHosp London England s & Genet Epidemiol Unit, London, England Univ Southampton, Southampton Gen Hosp, Sch Med, Human Genet Res Div, Southampton, Hants, England Univ Southampton Southampton Hants England , Southampton, Hants, England
Titolo Testata:
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 211 - 219
SICI:
0269-5022(200107)15:3<211:BVDRGA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; ELDERLY MEN; GENETIC-DETERMINANTS; POSTMENOPAUSAL WOMEN; CHILDHOOD GROWTH; CALCIUM INTAKE; MASS; POLYMORPHISMS; ALLELES; HYPOTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, C Univ Southampton, MRC, Environm Epidemiol Unit, Southampton Gen Hosp, Southampton, Hants, England Univ Southampton Southampton Hants England ton, Hants, England
Citazione:
E.M. Dennison et al., "Birthweight, vitamin D receptor genotype and the programming of osteoporosis", PAED PERIN, 15(3), 2001, pp. 211-219

Abstract

Studies of the association between polymorphisms of the gene for the vitamin D receptor (VDR) and adult bone mass have been inconsistent, pointing tothe possibility that gene-environment interactions may vary in different populations. We have demonstrated previously an association between weight in infancy (a marker of the intrauterine and early post-natal environment) and each of adult bone mass and VDR genotype. We therefore sought to extend these observations in an elderly UK cohort and to investigate the possibility of an interaction between these genetic and early environmental markers of later osteoporosis risk. One hundred and sixty-five men and 126 women aged 61-73 years for whom birth records were available underwent bone mass measurements at baseline and follow-up 4 years later. Whole-blood samples were obtained, DNA extracted using standard techniques and polymorphisms in the VDR and collagen type I alpha1 (Col IA1) genes identified. In the cohort as a whole, there were no significant associations between either birthweight or VDR genotype and bone mineral density (BMD) or bone loss rate at either site. However, the relationship between lumbar spine BMD and VDR genotype varied according to birthweight. Among individuals in the lowest third ofbirthweight, spine BMD was higher (P = 0.01) in individuals of genotype 'BB' after adjustment for age, sex and weight at baseline. In contrast, spineBMD was reduced (P = 0.04) in individuals of the same genotype who were inthe highest third of the birthweight distribution. A significant (P = 0.02) statistical interaction was also found between VDR genotype and birthweight as determinants of BMD. Similar but slightly weaker associations were seen between lumbar spine bone mineral content (BMC) and VDR genotype in the lowest birthweight tertile. When examining the relationship between Col1A1 genotype and bone mass, lumbar spine BMC was higher in individuals of genotype 'Ss' or 'ss' in the lowest birthweight tertile (P = 0.02) after adjustment for age, sex and weight at baseline. These results suggest that geneticinfluences on adult bone size and mineral density may be modified by undernutrition in utero.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:16:01