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Titolo:
EFFECT OF PRETREATMENT WITH HEPARIN ON PULMONARY AND CUTANEOUS RESPONSE
Autore:
KALPAKLIOGLU AF; DEMIREL YS; SARYAL S; MISIRLIGIL Z;
Indirizzi:
MENEVIS SOKAK 48-13 ASAGI AYRANCI TR-06540 ANKARA TURKEY ANKARA UNIV,FAC MED,DEPT ALLERG DIS TR-06100 ANKARA TURKEY
Titolo Testata:
The Journal of asthma
fascicolo: 4, volume: 34, anno: 1997,
pagine: 337 - 343
SICI:
0277-0903(1997)34:4<337:EOPWHO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-INDUCED AIRWAY; INHALED HEPARIN; ASTHMA; INHIBITION; MECHANISM; RELEASE;
Keywords:
METHACHOLINE; HEPARIN; BRONCHIAL HYPERREACTIVITY; AIRWAY RESISTANCE; SKIN TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.F. Kalpaklioglu et al., "EFFECT OF PRETREATMENT WITH HEPARIN ON PULMONARY AND CUTANEOUS RESPONSE", The Journal of asthma, 34(4), 1997, pp. 337-343

Abstract

Although anticoagulant properties of glycosaminoglycan heparin are primary in medicine, a variety of other biological functions related to heparin have been suggested. Since heparin is a selective inhibitor ofinositol triphosphate (IP3) receptors that are involved in release ofcalcium in mast cells and many other cells, it is possible that heparin may act as a natural anti-inflammatory molecule and modify these reactions. Therefore, the purpose of the present study was to determine the role of heparin in allergic inflammatory responses: the pulmonary reaction and the cutaneous response, in a double-blind, placebo-controlled, crossover randomized trial. To evaluate the effect of heparin onmethacholine-induced bronchoconstriction, nebulized heparin (20,000 units) was administered to 12 asthmatics and nonspecific challenge was performed immediately thereafter. Measurements of Raw and SGaw were obtained before and 1 hr after nebulization of heparin. In 12 other allergic subjects, heparin (25 U/kg) was given intravenously 10 min beforeskin prick test. We demonstrated that pretreatment with heparin reduced skin test reactivity from 24.06 +/- 1.2 mm to 18.26 +/- 2.27 mm andincreased the methacholine PC20 value from 1.69 +/- 0.48 mg/ml to 8.14 +/- 3.11 mg/ml (p < 0.05), but did not prevent an increase in Raw and/or a decrease in SGaw. Heparin modified the methacholine-induced bronchoconstrictor response, but this did not reflect a protective effectin airway resistance and specific conductance. These data suggest that anti-inflammatory effects of heparin are time-dependent and/or that heparin may have a transient inhibitory role in allergic reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:28:06