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Titolo:
Dopamine D5 receptor gene polymorphism and the risk of levodopa-induced motor fluctuations in patients with Parkinson's disease
Autore:
Wang, J; Liu, ZL; Chen, B;
Indirizzi:
Sun Yat Sen Univ Med Sci, Affiliated Hosp 1, Dept Neurol, Guangzhou 510080, Peoples R China Sun Yat Sen Univ Med Sci Guangzhou Peoples R China 510080 eoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 308, anno: 2001,
pagine: 21 - 24
SICI:
0304-3940(20010727)308:1<21:DDRGPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLICATIONS; BRAIN; RAT; D2;
Keywords:
Parkinson's disease; dopamine D5 receptor; gene polymorphism; motor fluctuations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, J Fudan Univ, Sch Life Sci, Inst Genet, 220 Handan Rd, Shanghai 200433, Peoples R China Fudan Univ 220 Handan Rd Shanghai Peoples R China 200433 R China
Citazione:
J. Wang et al., "Dopamine D5 receptor gene polymorphism and the risk of levodopa-induced motor fluctuations in patients with Parkinson's disease", NEUROSCI L, 308(1), 2001, pp. 21-24

Abstract

Motor fluctuations are the most common complication of levodopa therapy for Parkinson's disease (PD). Genetic factors could play a role in determining the occurrence of motor fluctuations. To investigate whether dopamine receptor D5 (DRDS) T978C polymorphism is associated with the risk of developing motor fluctuations in PD, we studied this polymorphism in a case-control study of 120 subjects with sporadic PD and 110 control subjects. We found that the overall allelic and genotypic frequencies did not differ significantly between patients with PD and control subjects (all P > 0.7), and between motor fluctuators (n = 50) and non-motor fluctuators (n = 50) (all P > 0.8). It suggests that DRDS T978C polymorphism is not associated with the susceptibility to PD, nor with the risk of developing motor fluctuations in PD. Therefore, other polymorphisms that alter the expression of the dopamine receptors should be further studied. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:49:59