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Titolo:
Lack of the involvement of mu(1)-opioid receptor subtype on motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and-2 in the mouse
Autore:
Narita, M; Ozaki, S; Ioka, M; Mizoguchi, H; Nagase, H; Tseng, LF; Suzuki, T;
Indirizzi:
Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 xicol, Shinagawa Ku, Tokyo 1428501, Japan Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hesiol, Milwaukee, WI 53226 USA Toray Ind Inc, Pharmaceut Res Lab, Dept Med Chem, Kanagawa 2488555, Japan Toray Ind Inc Kanagawa Japan 2488555 t Med Chem, Kanagawa 2488555, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 308, anno: 2001,
pagine: 17 - 20
SICI:
0304-3940(20010727)308:1<17:LOTIOM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; PLACE PREFERENCE; CXBK MOUSE; MORPHINE; RAT; EXPRESSION; BINDING; BRAIN; MICE;
Keywords:
endomorphin-1; endomorphin-2; motivational effect; mu-opioid receptor subtypes; CXBK mice; lower midbrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, 2-4-41 Ebara,Tokyo 1428501, Japan Hoshi Univ 2-4-41 Ebara Tokyo Japan 1428501 okyo 1428501, Japan
Citazione:
M. Narita et al., "Lack of the involvement of mu(1)-opioid receptor subtype on motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and-2 in the mouse", NEUROSCI L, 308(1), 2001, pp. 17-20

Abstract

The present study was designed to investigate the role of mu -opioid receptor subtypes in the motivational effect of endogenous mu -opioid receptor ligands, endomorphin-1 and -2. In C57BL/6J mice, endomorphin-1 produced a significant place preference, whereas endomorphin-2 exhibited a significant place aversion. These effects were abolished by a mu (1)/mu (2)-opioid receptor antagonist beta -funaltrexamine. Under these conditions, both endomorphin-1 and -2 produced their motivational effects in mu (1)-opioid receptor-deficient CXBK mice, indicating the mu (2)-opioid receptor involvement. Furthermore, in the lower midbrain including ventral tegmental area, both endomorphin-1 and -2 equally produced dose-related increases in guanosine-5'-o-(3-[S-35] thio) triphosphate bindings in C57BL/6J and CXBK mice. These findings indicate that endomorphin-1 and -2 may produce distinct motivational effects via respective mu (2)-opioid receptor isoforms in the mouse. Furthermore, endomorphin-1 and -2 produced the yl-resistant G-protein activation inthe mouse lower midbrain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:29:22