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Titolo:
Visceral antinociception produced by bee venom stimulation of the Zhongwanacupuncture point in mice: role of alpha(2) adrenoceptors
Autore:
Kwon, YB; Kang, MS; Han, HJ; Beitz, AJ; Lee, JH;
Indirizzi:
Seoul Natl Univ, Coll Vet Med, Dept Vet Physiol, Suwon 441744, South KoreaSeoul Natl Univ Suwon South Korea 441744 siol, Suwon 441744, South Korea Seoul Natl Univ, Sch Agr Biotechnol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 hnol, Suwon 441744, South Korea Chonnam Natl Univ, Hormone Res Ctr, Kwangju, South Korea Chonnam Natl Univ Kwangju South Korea one Res Ctr, Kwangju, South Korea Chonnam Natl Univ, Coll Vet Med, Kwangju, South Korea Chonnam Natl Univ Kwangju South Korea oll Vet Med, Kwangju, South Korea Univ Minnesota, Coll Vet Med, Dept Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Vet Pathobiol, St Paul, MN 55108 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 308, anno: 2001,
pagine: 133 - 137
SICI:
0304-3940(20010803)308:2<133:VAPBBV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-LIKE IMMUNOREACTIVITY; SPINAL-CORD; CONSCIOUS RAT; MORPHINE; PAIN; TRANSMISSION; INVOLVEMENT; INJECTION; STIMULUS; NUCLEUS;
Keywords:
bee venom; antinociception; acupuncture; abdominal nociception; fos expression; adrenoceptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JH Seoul Natl Univ, Coll Vet Med, Dept Vet Physiol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 won 441744, South Korea
Citazione:
Y.B. Kwon et al., "Visceral antinociception produced by bee venom stimulation of the Zhongwanacupuncture point in mice: role of alpha(2) adrenoceptors", NEUROSCI L, 308(2), 2001, pp. 133-137

Abstract

The goal of the present study was to determine whether bee venom (BV) injection into the Zhongwan acupoint (CV12), compared to injection into a non-acupoint, produced antinociception in an acetic acid-induced visceral pain model. This was accomplished by injecting BV subcutaneously into the Zhongwan acupoint or into a non-acupoint 30 min before intraperitoneal injection of acetic acid in ICR mice. BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii. In contrast BV injection into the non-acupoint only produced antinociception at the highest dose of BV tested. Naloxone pretreatment did notalter the antinociceptive effect of BV acupoint injection on the abdominalstretch reflex. On the other hand, pretreatment with the alpha2-adrenoceptor antagonist, yohimbine completely blocked the antinociceptive effect of BV acupoint injection. These results imply that BV acupoint stimulation can produce visceral antinociception that is associated with activation of alpha2-adrenoceptors, but not with naloxone-sensitive opioid receptors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 23:40:56