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Titolo:
Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum
Autore:
Obata, T; Kubota, S;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Physiol Chem & Metab, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 & Metab, Bunkyo Ku, Tokyo 1130033, Japan Oita Med Univ, Dept Pharmacol, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 iv, Dept Pharmacol, Oita 8795593, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 308, anno: 2001,
pagine: 87 - 90
SICI:
0304-3940(20010803)308:2<87:PEOTO1>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURODEGENERATIVE DISEASES; POSTMENOPAUSAL WOMEN; MEMBRANE ANTIOXIDANT; BREAST-CANCER; MICRODIALYSIS; ESTROGEN; PARKINSONISM; MPP+; ACID;
Keywords:
striatum; tamoxifen; 1-methyl-4-phenylpyridine; hydroxyl radical; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kubota, S Univ Tokyo, Grad Sch Med, Dept Physiol Chem & Metab, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
T. Obata e S. Kubota, "Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum", NEUROSCI L, 308(2), 2001, pp. 87-90

Abstract

We examined whether tamoxifen could suppress 1-methyl-4-phenylpyridine (MPP+)-induced hydroxyl radical generation in the extracellular fluid of rat striatum, using in vivo microdialysis system. MPP+ (5 mM) enhanced generation of hydroxyl radicals with concomitant increased efflux of dopamine. Tamoxifen (1-100 muM) dose-dependently suppressed the hydroxyl radical formationinduced by MPP+. Tamoxifen (100 muM) significantly attenuated dopamine efflux induced by MPP+. The result in the present study is the first demonstration showing the protective effect of tamoxifen on hydroxyl radical generation induced by MPP+ by suppressing dopamine efflux. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 19:07:28