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Titolo:
Electrophysiological evidence for postsynaptic 5-HT1A receptor control of dorsal raphe 5-HT neurones
Autore:
Martin-Ruiz, R; Ugedo, L;
Indirizzi:
Univ Basque Country, Fac Med, Dept Pharmacol, Leioa, Vizcaya, Spain Univ Basque Country Leioa Vizcaya Spain Pharmacol, Leioa, Vizcaya, Spain CSIC, IIBB, Dept Neurochem, Barcelona, Spain CSIC Barcelona SpainCSIC, IIBB, Dept Neurochem, Barcelona, Spain
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 1, volume: 41, anno: 2001,
pagine: 72 - 78
SICI:
0028-3908(200107)41:1<72:EEFP5R>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; SEROTONERGIC NEURONS; RAT-BRAIN; 5-HYDROXYTRYPTAMINE RELEASE; EFFERENT PROJECTIONS; 8-OH-DPAT; INHIBITION; NUCLEUS; HIPPOCAMPUS; AGONISTS;
Keywords:
5-HT1A receptors; pertussis toxin; G(i)/G(o) proteins; 8-OH-DPAT; pressure microinjection; single unit recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ugedo, L Univ Basque Country, Fac Med, Dept Pharmacol, Leioa, Vizcaya, Spain Univ Basque Country Leioa Vizcaya Spain , Leioa, Vizcaya, Spain
Citazione:
R. Martin-Ruiz e L. Ugedo, "Electrophysiological evidence for postsynaptic 5-HT1A receptor control of dorsal raphe 5-HT neurones", NEUROPHARM, 41(1), 2001, pp. 72-78

Abstract

Postsynaptic 5-hydroxytryptamine(1A) (5-HT1A) receptors have been proposedto participate in the control of dorsal raphe 5-HT neurone activity. To further investigate this hypothesis we performed single-unit extracellular recordings in anaesthetized rats. Pertussis toxin (2 mug/4 mul/day; 2 days, 24-72 h before the experiment) was applied close to the dorsal raphe nucleusto uncouple somatodendritic 5-HT1A autoreceptors from their effector system. After this treatment the spontaneous firing rate was higher (similar to 60% P < 0.005) than in the vehicle-pretreated group. In addition, intravenous administration of 8-hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) inhibited 5 out of 11 cells of the pertussis toxin-pretreated group (ED50=1.65<plus/minus>0.94 mug/kg), whereas in the vehicle-pretreated group, alltested cells were inhibited (ED50=1.87 +/-0.39 mug/kg). Local administration of 8-OH-DPAT did not affect cells (n = 12) in pertussis toxin-pretreatedrats, even at doses much higher than those needed to completely inhibit 5-HT cells in vehicle-pretreated rats (ED50=3.34 +/-0.62 fmol). These resultsconfirm the involvement of distal postsynaptic 5-HT1A receptors in the control of 5-HT neurone activity in the dorsal raphe nucleus. However, this control does not appear to be exerted on all 5-HT neurones, but rather on a subpopulation of them. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:20:08