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Titolo:
The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats
Autore:
Schulz, B; Fendt, M; Gasparini, F; Lingenhohl, K; Kuhn, R; Koch, M;
Indirizzi:
Univ Bremen, Brain Res Inst, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 ain Res Inst, D-28334 Bremen, Germany Univ Tubingen, Tubingen, Germany Univ Tubingen Tubingen GermanyUniv Tubingen, Tubingen, Germany Novartis Pharma AG, Basel, Switzerland Novartis Pharma AG Basel Switzerland rtis Pharma AG, Basel, Switzerland
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 1, volume: 41, anno: 2001,
pagine: 1 - 7
SICI:
0028-3908(200107)41:1<1:TMGRA2>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; LONG-TERM POTENTIATION; NMDA RECEPTORS; AMYGDALA; SENSITIZATION; EXPRESSION; MEMORY; BRAIN; HIPPOCAMPUS; INCREASE;
Keywords:
acoustic startle response; fear; learning; memory; metabotropic glutamate receptors; prepulse inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, M Univ Bremen, Brain Res Inst, POB 33 04 40, D-28334 Bremen, GermanyUniv Bremen POB 33 04 40 Bremen Germany D-28334 4 Bremen, Germany
Citazione:
B. Schulz et al., "The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats", NEUROPHARM, 41(1), 2001, pp. 1-7

Abstract

Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) was applied systemically (0.0, 0.3, 3.0, 30.0 mg/kg per os) 60 min before the acquisition training and before the expression of conditioned fear, respectively, in the fear-potentiated startle paradigm. MPEP dose-dependently blocked the acquisition of fear. This effect was not due to state-dependent learning. MPEP also prevented the expression of fear at a dose of 30.0 mg/kg. As a positive control for these effects, we showed that the benzodiazepine anxiolytic compound diazepam (1.25 mg/kg intraperitoneally) also blocked acquisition and expression of fear potentiated startle. MPEP did not affect the baseline startle magnitude, short-term habituation of startle, sensitisation of startle by footshocks or prepulse inhibition of startle. These data indicate a crucial role for mGluR5 in the regulation of fear conditioning. In the highest dose MPEP might exert anxiolytic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:19:17