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Titolo:
Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy
Autore:
Aronica, E; Yankaya, B; Jansen, GH; Leenstra, S; van Veelen, CWM; Gorter, JA; Troost, D;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Neurosurg, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands Stichting Epilepsie Instellingen Nederland Heemstede Netherlands rlands Univ Med Ctr Utrecht, Dept Neuropathol, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands ropathol, Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Neurosurg, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands eurosurg, Utrecht, Netherlands Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands t Life Sci, Amsterdam, Netherlands
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 3, volume: 27, anno: 2001,
pagine: 223 - 237
SICI:
0305-1846(200106)27:3<223:IAMGRP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; FOCAL CORTICAL DYSPLASIA; CENTRAL-NERVOUS-SYSTEM; NEURONS IN-VITRO; NMDA-RECEPTORS; SUBUNIT IMMUNOREACTIVITY; MESSENGER-RNA; UP-REGULATION; SPINAL-CORD; IMMUNOHISTOCHEMICAL LOCALIZATION;
Keywords:
brain tumours; dysembryoplastic neuroepithelial tumours; epilepsy; gangliogliomas; glutamate receptors; immunocytochemistry; perilesional reactive astrocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Aronica, E Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, Meibergdreef 9,NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
E. Aronica et al., "Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy", NEUROP AP N, 27(3), 2001, pp. 223-237

Abstract

Glioneuronal tumours are an increasingly recognized cause of chronic pharmaco-resistant epilepsy. In the present study the immunocytochemical expression of various glutamate receptor (GluR) subtypes was investigated in 41 gangliogliomas (GG) and 16 dysembryoplastic neuroepithelial tumours (DNT) from patients with intractable epilepsy. Immunocytochemistry with antibodies specific for ionotropic NR1, NR2A/B (NMDA) GluR1, GluR2 (AMPA), GluR5-7 (kainate), and metabotropic mGluR1, mGluR2-3, mGluR5, mGluR7a subtypes demonstrated in both GG and DNT the presence of an highly differentiated neuronal population, containing subunits from each receptor class. More than 50% of tumours contained a high percentage of neuronal cells immunolabelled for NMDA, AMPA and kainate receptor subunits. A high percentage of neurones showedstrong expression of NR2A-B, which co-localized with NR1. Group I mGluRs (mGluR1 and mGluR5) were highly represented in the neuronal component of thetumours. Immunolabelling for several GluRs was also present in the glial component. Increased expression of mGluR2-3, mGluR5 and GluR5-7 was observedin reactive astrocytes in the perilesional zone compared to normal cortex. The neurochemical profile of glioneuronal tumours, with high expression ofspecific GluR subtypes, supports the central role of glutamatergic transmission in the mechanisms underlying the intrinsic and high epileptogenicity of these lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 22:36:30