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Titolo:
The relationship between alpha B-crystallin and neurofibrillary tangles inAlzheimer's disease
Autore:
Mao, JJ; Katayama, S; Watanabe, C; Harada, Y; Noda, K; Yamamura, Y; Nakamura, S;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Internal Med 3, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Hiroshima Univ, Sch Med, Inst Hlth Sci, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Natl Hara Sanat Hosp, Dept Neurol, Hatsukaichi, Japan Natl Hara Sanat Hosp Hatsukaichi Japan Dept Neurol, Hatsukaichi, Japan Natl Hiroshima Sanat Hosp, Dept Neurol, Higashihiroshima, Japan Natl Hiroshima Sanat Hosp Higashihiroshima Japan igashihiroshima, Japan
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 3, volume: 27, anno: 2001,
pagine: 180 - 188
SICI:
0305-1846(200106)27:3<180:TRBABA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; NON-LENTICULAR TISSUES; BALLOONED NEURONS; NEURODEGENERATIVE DISEASES; NONLENTICULAR TISSUES; IMMUNOREACTIVE ALPHA; LENS CRYSTALLINS; SENILE PLAQUES; PROTEIN; EXPRESSION;
Keywords:
alpha B-crystallin positive neurones; Alzheimer's disease; diffuse senile plaques; classical senile plaques; intracellular neurofibrillary tangles; extracellular neurofibrillary tangles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Katayama, S Hiroshima Univ, Sch Med, Dept Internal Med 3, Minami Ku, 1-2-3Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 51, Japan
Citazione:
J.J. Mao et al., "The relationship between alpha B-crystallin and neurofibrillary tangles inAlzheimer's disease", NEUROP AP N, 27(3), 2001, pp. 180-188

Abstract

alphaB-crystallin is known as a small heat shock protein with a cytoprotective function. This study was undertaken to investigate the relationship between alphaB-crystallin and changes seen in Alzheimer's disease. The distribution and immunohistochemical characteristics of alphaB-crystallin positive neurones in the cerebral cortices of 4 patients with Alzheimer's disease were examined. alphaB-crystallin positive neurones were mainly distributed in the limbic and paralimbic regions, namely parahippocampal gyrus, fusiform gyrus, cingulate cortex, middle and superior frontal gyrus, and insular cortex, which corresponded to commonly affected regions in Alzheimer's disease. Moreover, such neurones were present predominantly in the III or V layer of the cerebral cortex. The number of alphaB-crystallin positive neuronesincreased in parallel with the neuronal loss. Logistic regression analysisrevealed a significant relation between the density of alphaB-crystallin positive neurones and that of extracellular neurofibrillary tangles (NFTs), with a correlation coefficient (r) of 0.57 and P < 0.0001 in 14 regions of the cerebral cortex. In contrast, the relation was not statistically significant between the density of alphaB-crystallin positive neurones and that of classical senile plaques, diffuse plaques or intracellular NFTs. ModifiedGallyas-Braak (GB) staining on alphaB-crystallin positive neurone demonstrated several patterns of the structures: faint GB positive structures in the swollen perikaryon with straight neurites, fine granules compressed and contorted into fuzzy bundles, intensely GB positive filamentous structures together with fine granules and very intensely GB positive ring-like NFTs ina swollen perikaryon with curved neurites. In positive neurones, the density of ring-like NFTs correlated with that of atrophic perikaryon, or bent neurites and a decrease in the immuoreactivity of alphaB-crystallin. These data suggest that a close relationship exists between the appearance of alphaB-crystallin in neurones, extracellular NFTs, and neurofibrillary formation in alphaB-crystallin positive neurones in Alzheimer brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:14:06