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Titolo:
Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
Autore:
Ji, D; Lape, R; Dani, JA;
Indirizzi:
Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Div Neurosci, Houston, TX 77030 USA Baylor Coll Med, Struct & Computat Biol & Mol Biophys Program, Houston, TX77030 USA Baylor Coll Med Houston TX USA 77030 iophys Program, Houston, TX77030 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 31, anno: 2001,
pagine: 131 - 141
SICI:
0896-6273(20010719)31:1<131:TALONA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR ACTIVATION; LONG-TERM POTENTIATION; RAT HIPPOCAMPUS; CHANNEL DOMAIN; DENTATE GYRUS; ACH RECEPTORS; INTERNEURONS; NEURONS; BRAIN; TRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Dani, JA Baylor Coll Med, Div Neurosci, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 TX 77030 USA
Citazione:
D. Ji et al., "Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity", NEURON, 31(1), 2001, pp. 131-141

Abstract

This study reveals mechanisms in the mouse hippocampus that may underlie nicotinic influences on attention, memory, and cognition. Induction of synaptic plasticity, arising via generally accepted mechanisms, is modulated by nicotinic acetylcholine receptors. Properly timed nicotinic activity at pyramidal neurons boosted the induction of long-term potentiation via presynaptic and postsynaptic pathways. On the other hand, nicotinic activity on interneurons inhibited nearby pyramidal neurons and thereby prevented or diminished the induction of synaptic potentiation. The synaptic modulation was dependent on the location and timing of the nicotinic activity. Loss of these synaptic mechanisms may contribute to the cognitive deficits experienced during Alzheimer's diseases, which is associated with a loss of cholinergicprojections and with a decrease in the number of nicotinic receptors.

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Documento generato il 26/01/20 alle ore 01:01:43