Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion
Autore:
Glatzel, M; Heppner, FL; Albers, KM; Aguzzi, A;
Indirizzi:
Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Kentucky, Coll Med, Dept Pathol & Lab Med, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 l & Lab Med, Lexington, KY 40536 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 31, anno: 2001,
pagine: 25 - 34
SICI:
0896-6273(20010719)31:1<25:SIOLOI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NERVOUS-SYSTEM; FOLLICULAR DENDRITIC CELLS; SCRAPIE AGENT; MOUSE SCRAPIE; CHEMICAL SYMPATHECTOMY; LYMPHOID-TISSUES; IMMUNE-SYSTEM; SPINAL-CORD; IN-VIVO; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Aguzzi, A Univ Zurich Hosp, Inst Neuropathol, Schmelzbergstr 12, CH-8091 Zurich, Switzerland Univ Zurich Hosp Schmelzbergstr 12 Zurich Switzerland CH-8091 d
Citazione:
M. Glatzel et al., "Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion", NEURON, 31(1), 2001, pp. 25-34

Abstract

Transmissible spongiform encephalopathies are commonly propagated by extracerebral inoculation of the infectious agent. Indirect evidence suggests that entry into the central nervous system occurs via the peripheral nervous system. Here we have investigated the role of the sympathetic nervous system in prion neuroinvasion. Following intraperitoneal prion inoculation, chemical or immunological sympathectomy delayed or prevented scrapie. Prion titers in spinal cords were drastically reduced at early time points after inoculation. Instead, keratin 14-NGF transgenic mice, whose lymphoid organs are hyperinnervated by sympathetic nerves, showed reduction in scrapie incubation time and, unexpectedly, much higher titers of prion infectivity in spleens. We conclude that sympathetic innervation of lymphoid organs is rate limiting for prion neuroinvasion and that splenic sympathetic nerves may actas extracerebral prion reservoirs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:33:33