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Titolo:
Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering
Autore:
Foundas, AL; Bollich, AM; Corey, DM; Hurley, M; Heilman, KM;
Indirizzi:
Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 & Neurol, New Orleans, LA 70112 USA Tulane Univ, Hlth Sci Ctr, Dept Psychol, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 t Psychol, New Orleans, LA 70112 USA Dept Vet Affairs Med Ctr, Neurol Serv, New Orleans, LA USA Dept Vet Affairs Med Ctr New Orleans LA USA ol Serv, New Orleans, LA USA Univ Florida, Hlth Sci Ctr, Inst Brain, Dept Neurol, Gainesville, FL USA Univ Florida Gainesville FL USA Brain, Dept Neurol, Gainesville, FL USA Dept Vet Affairs Med Ctr, Neurol Serv, Gainesville, FL USA Dept Vet Affairs Med Ctr Gainesville FL USA ol Serv, Gainesville, FL USA
Titolo Testata:
NEUROLOGY
fascicolo: 2, volume: 57, anno: 2001,
pagine: 207 - 215
SICI:
0028-3878(20010724)57:2<207:AAOSAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; PLANUM TEMPORALE ASYMMETRY; SYLVIAN FISSURE MORPHOLOGY; PARS TRIANGULARIS; BRAIN MORPHOLOGY; MRI FINDINGS; DYSLEXIA; HANDEDNESS; DOMINANCE; OPERCULARIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Foundas, AL Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, 1430 TulaneAve TB52, New Orleans, LA 70112 USA Tulane Univ 1430 Tulane Ave TB52 New Orleans LA USA 70112 USA
Citazione:
A.L. Foundas et al., "Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering", NEUROLOGY, 57(2), 2001, pp. 207-215

Abstract

Objective: The major aim of this study was to determine whether adults with persistent developmental stuttering (PDS) have anomalous anatomy in cortical speech-language areas. The major postulate was that anomalous cerebral dominance, reflected by anomalous cortical anatomy in various regions, may put an individual at increased risk for the development of stuttering. Methods: Adults with PDS (n = 16) and controls (n = 16) matched for age, sex, hand preference, and education were studied. Volumetric MRI scans were completed. Frontal (pars triangularis, pars opercularis) and temporo-parietal areas (planum temporale, posterior ascending ramus) were measured in the leftand right hemispheres and interhemispheric asymmetries were computed. Gyral variants were assessed within these perisylvian cortical speech-language areas. Results: The right and left planum temporale were significantly larger in the adults with PDS (p = 0.045), and the magnitude of the planar asymmetry was reduced (p = 0.003). Some gyral variants were unique to the adults with PDS, including a second diagonal sulcus and extra gyri along the superior bank of the sylvian fossa. In addition, anatomic subgroups emerged based on sex and hand preference. Overall, the adults with PDS had significantly more gyral variants (mean = 4.19) than controls (mean = 1.31, p < 0.0005). Conclusions: These results provide strong evidence that adults with PDShave anomalous anatomy in perisylvian speech and language areas. No one anatomic feature distinguished the groups, but multiple loci within a widely distributed neural network differed between groups. These results provide the first evidence that anatomic anomalies within perisylvian speech-language areas may put an individual at risk for the development of stuttering.

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Documento generato il 21/01/20 alle ore 07:33:48