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Titolo:
Maternal undernutrition induces neuroendocrine immune dysfunction in male pups at weaning
Autore:
Chisari, AN; Giovambattista, A; Perello, M; Gaillard, RC; Spinedi, E;
Indirizzi:
CIC CONICET, Neuroendocrine Unit, Multidisciplinary Inst Cell Biol, La Plata, Argentina CIC CONICET La Plata Argentina nary Inst Cell Biol, La Plata, Argentina UNLP, Sch Exact Sci, La Plata, Argentina UNLP La Plata ArgentinaUNLP, Sch Exact Sci, La Plata, Argentina Univ Hosp, Div Endocrinol Diabetol & Metab, Lausanne, Switzerland Univ Hosp Lausanne Switzerland Diabetol & Metab, Lausanne, Switzerland
Titolo Testata:
NEUROIMMUNOMODULATION
fascicolo: 1, volume: 9, anno: 2001,
pagine: 41 - 48
SICI:
1021-7401(2001)9:1<41:MUINID>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; SEVERELY MALNOURISHED CHILDREN; NECROSIS-FACTOR-ALPHA; GLUCOCORTICOID RECEPTOR; LEPTIN; RATS; INTERLEUKIN-1; MALNUTRITION; STRESS; FOOD;
Keywords:
lipopolysaccharide; ACTH; glucocorticoid; carbohydrate; tumor necrosis factor-alpha; leptin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Spinedi, E IMBICE, 526 E-10 & 11, RA-1900 La Plata, Argentina IMBICE 526 E-10 & 11 La Plata Argentina RA-1900 ata, Argentina
Citazione:
A.N. Chisari et al., "Maternal undernutrition induces neuroendocrine immune dysfunction in male pups at weaning", NEUROIMMUNO, 9(1), 2001, pp. 41-48

Abstract

The present study was designed to assess the effect of maternal undernutrition, during gestation and lactation, on the neuroendocrine [hypothalamo-pituitary-adrenal (HPA)]-immune axis response to endotoxin (LPS) administration. For this purpose, 21-day-old male rats from both well-nourished (WN) and undernourished (UN) mothers were examined 2 h after injection (i.p.) of vehicle alone (VEH) or containing LPS (130 mug/kg BW). Circulating levels ofglucose (GLU), ACTH, corticosterone (B), tumor necrosis factor-alpha (TNF alpha) and leptin were explored. The results indicate that: (a) mother bodyweight was significantly (p < 0.05) reduced, as a consequence of UN, at the second and third weeks of pregnancy; (b) no differences in basal glycemiawere found in the two groups of pups, and LIPS treatment did not induce hypoglycemia, in either group; (c) basal plasma ACTH, B and TNFa levels were similar in the two groups, and LPS-induced ACTH, B and TNFa secretions, although severalfold higher than respective VEH values (p < 0.05) in pups fromWN mothers, were fully (ACTH and B) and partially (TNF alpha) abolished inproducts from UN mothers; (d) both mean body weights and basal plasma leptin levels were significantly (p < 0.05) lower in pups from UN than from WN mothers, and LPS administration did not modify plasma leptin values in products from both groups. In addition, results of dispersed total adrenal cells incubated in vitro indicate that: (a) both basal and ACTH (22 pM)-inducedB secretion were significantly (p < 0.05) lower in cells from UN than WN pups, and (b) leptin (100 nM) was able to inhibit partially ACTH-stimulated B output by adrenal gland (AG) cells from WN pups; however, it failed to inhibit ACTH-stimulated glucocorticoid release by AG cells from UN pups. The present results indicate that undernutrition in mothers, during the very critical periods of gestation and lactation, induces in their male pups at weaning: (a) reduced circulating leptin levels and body weight values; (b) metabolic adaptation to normal carbohydrate metabolism; (c) hyporesponsiveness of the HPA and immune (TNFa) axes during endotoxemia, and (d) leptin resistance at the adrenocortical level. This study strongly supports that undernutrition of mothers results in neuroendocrine immune dysfunction of their pups; however, adrenal resistance to the inhibitory effect of leptin on glucocorticoid output is developed, probably as an adaptive mechanism to counteract unfavorable metabolic conditions. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:57:18