Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease
Autore:
Schneider, J; Jehle, EC; Starlinger, MJ; Neunlist, M; Michel, K; Hoppe, S; Schemann, M;
Indirizzi:
Hannover Sch Vet Med, Dept Physiol, D-30173 Hannover, Germany Hannover SchVet Med Hannover Germany D-30173 D-30173 Hannover, Germany Univ Tubingen, Dept Gen Surg, Tuebingen, Germany Univ Tubingen TuebingenGermany ngen, Dept Gen Surg, Tuebingen, Germany
Titolo Testata:
NEUROGASTROENTEROLOGY AND MOTILITY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 255 - 264
SICI:
1350-1925(200106)13:3<255:NCOENI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; INFLAMMATORY BOWEL-DISEASE; NEUROPEPTIDE-CONTAINING NERVES; MYENTERIC NEURONS; HUMAN COLON; ULCERATIVE-COLITIS; SENSORY NEURONS; HUMAN GUT; PEPTIDE; IMMUNOREACTIVITY;
Keywords:
Crohn's disease; enteric nervous system; human; neurochemical code; transmitters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Schemann, M Hannover Sch Vet Med, Dept Physiol, Bischofsholer Damm 15, D-30173 Hannover, Germany Hannover Sch Vet Med Bischofsholer Damm 15 HannoverGermany D-30173
Citazione:
J. Schneider et al., "Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease", NEUROG MOT, 13(3), 2001, pp. 255-264

Abstract

Knowledge of the neurochemical coding of submucosal neurones in the human gut is important to assess neuronal changes under pathological conditions. We therefore investigated transmitter colocalization patterns in rectal submucosal neurones in normal tissue (n=11) and in noninflamed tissue of Crohn's disease (CD) patients (n=17). Neurone-specific enolase (NSE), choline acetyltransferase (ChAT), vasoactive intestinal polypeptide (VIP), substance P (SP), nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) were detected immunohistochemically in whole-mount preparations from rectal biopsies. The neuronal marker NSE revealed no differences in the number of cells per ganglion (controls 5.0; CD 5.1). Four cell populations with distinct neurochemical codes were identified. The sizes of the populations ChAT/VIP (58% vs. 55%), ChAT/SP (8% vs. 8%), and ChAT/- (22% vs. 22%) were similar in control and CD. The population VIP/- was significantly increasedin CD (12% vs. 2% in controls). Unlike in controls, all NOS neurones colocalized ChAT in CD. Thickened CGRP-fibres occurred in CD. We identified neurochemically distinct populations in the human submucous plexus. The increase in the VIP/- population, extensive colocalization of ChAT and NOS and hypertrophied CGRP fibres indicated adaptive changes in the enteric nervous system in noninflamed rectum of CD patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:17:33