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Titolo:
Oesophageal pressure-cross-sectional area distributions and secondary peristalsis in relation to subclassification of systemic sclerosis
Autore:
Villadsen, GE; Storkholm, J; Zachariae, H; Hendel, L; Bendtsen, F; Gregersen, H;
Indirizzi:
Univ Aalborg, Ctr Sensory Motor Interact, DK-9220 Aalborg, Denmark Univ Aalborg Aalborg Denmark DK-9220 Interact, DK-9220 Aalborg, Denmark Aarhus Univ Hosp, Dept Med 5, Sect AKH, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 ect AKH, DK-8000 Aarhus, Denmark Aarhus Univ Hosp, Inst Expt Clin Res, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 lin Res, DK-8000 Aarhus, Denmark Dept Dermatol, Aarhus, Denmark Dept Dermatol Aarhus DenmarkDept Dermatol, Aarhus, Denmark Rigshosp, Dept Dermatol, DK-2100 Copenhagen, Denmark Rigshosp CopenhagenDenmark DK-2100 ermatol, DK-2100 Copenhagen, Denmark Univ Copenhagen, Hvidovre Hosp, Dept Med Gastroenterol, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark d Gastroenterol, Copenhagen, Denmark Dept Surg A, Aalborg, Denmark Dept Surg A Aalborg DenmarkDept Surg A, Aalborg, Denmark
Titolo Testata:
NEUROGASTROENTEROLOGY AND MOTILITY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 199 - 210
SICI:
1350-1925(200106)13:3<199:OPADAS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOTERMINAL PROPEPTIDE; GASTROINTESTINAL-TRACT; III PROCOLLAGEN; CREST SYNDROME; SCLERODERMA; ESOPHAGUS; DISEASE; REFLUX; MANIFESTATIONS; CLASSIFICATION;
Keywords:
distensibility; oesophagus; manometry; secondary peristalsis; systemic sclerosis; tension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gregersen, H Univ Aalborg, Ctr Sensory Motor Interact, Fredrik Bajers Vej 7D-3, DK-9220Aalborg, Denmark Univ Aalborg Fredrik Bajers Vej 7D-3 AalborgDenmark DK-9220
Citazione:
G.E. Villadsen et al., "Oesophageal pressure-cross-sectional area distributions and secondary peristalsis in relation to subclassification of systemic sclerosis", NEUROG MOT, 13(3), 2001, pp. 199-210

Abstract

The aim of the present study was to correlate the severity of oesophageal motor dysfunction with the severity of cutaneous disease in systemic sclerosis (SS). Patients were divided into three groups based on the degree of skin involvement: type I, acrosclerosis distal to the wrist; type II, scleroderma extending above the wrist in proximal direction; type III, diffuse cutaneous systemic sclerosis. Impedance planimetry employing distensions with pressures up to 5 kPa with the concomitant measurement of oesophageal cross-sectional area (CSA) was used in combination with standard oesophageal manometry. Measurements were made at 7 and 15 cm above the lower oesophageal sphincter (LOS). Thirty patients (16 type I, six type II and eight type III patients) and 23 normal controls were included. LOS pressure was lower in SS patients than in normal patients, with the lowest values in type III. TheCSAs were higher in SS patients than in controls at both sites (P < 0.001). The CSAs at the distal site were highest in type III, as compared to typeI and II (P < 0.03). The CSA at the highest induced pressure (5.0 kPa) was613 +/- 45, 719 +/- 79, and 808 +/- 115 mm(2) in types I, II and III, respectively. No differences in CSA were found at the proximal site between thethree types of SS. The distensibility did not differ between SS and normalpatients at the distal site. The distensibility was lowest in SS patients (P < 0.001) at the proximal distension site. The distensibility did not vary with the type of SS at either site. Significant differences in contraction frequency of the secondary peristalsis as function of wall tension were demonstrated between the SS patients and controls at the distal site (P < 0.05). No differences were found at the proximal site. The contraction frequency and amplitude at the distal and proximal sites did not differ among thethree types. In conclusion for most parameters studied, SS patients differed from normal patients. Among SS types, the most pronounced changes were found in type III.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:05:33