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Titolo:
Precursor RNAs harboring nonsense codons accumulate near the site of transcription
Autore:
Muhlemann, O; Mock-Casagrande, CS; Wang, J; Li, SL; Custodio, N; Carmo-Fonseca, M; Wilkinson, MF; Moore, MJ;
Indirizzi:
Brandeis Univ, Howard Hughes Med Inst, WM Keck Ctr Cellular Visualizat, Dept Biochem, Waltham, MA 02454 USA Brandeis Univ Waltham MA USA 02454 t, Dept Biochem, Waltham, MA 02454 USA Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Dept Immunol, Houston, TX 77030 USA Univ Lisbon, Fac Med, Inst Histol & Embryol, P-1699 Lisbon, Portugal Univ Lisbon Lisbon Portugal P-1699 ol & Embryol, P-1699 Lisbon, Portugal
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 8, anno: 2001,
pagine: 33 - 43
SICI:
1097-2765(200107)8:1<33:PRHNCA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-MESSENGER-RNA; PREMATURE TERMINATION CODON; HIGHLY LOCALIZED TRACKS; FRAME-DEPENDENT MANNER; LIGHT-CHAIN GENES; MEDIATED DECAY; SPLICING ENHANCER; CYTOPLASMIC TRANSLATION; REGULATORY MECHANISM; PROTEIN-SYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, MJ Brandeis Univ, Howard Hughes Med Inst, WM Keck Ctr Cellular Visualizat, Dept Biochem, Waltham, MA 02454 USA Brandeis Univ Waltham MA USA 02454 ochem, Waltham, MA 02454 USA
Citazione:
O. Muhlemann et al., "Precursor RNAs harboring nonsense codons accumulate near the site of transcription", MOL CELL, 8(1), 2001, pp. 33-43

Abstract

Messenger RNAs containing premature termination codons (PTCs) are selectively eliminated by nonsensemediated mRNA decay (NMD). Paradoxically, although cytoplasmic ribosomes are the only known species capable of PTC recognition, in mammals many PTC-containing mRNAs are apparently eliminated prior torelease from the nucleus. To determine whether PTCs can influence events within the nucleus proper, we studied the immunoglobulin (Ig)-mu and T cell receptor (TCR)-beta genes using fluorescent in situ hybridization (FISH). Alleles containing PTCs, but not those containing a missense mutation or a frameshift followed by frame-correcting mutations, exhibited elevated levelsof pre-mRNA, which accumulated at or near the site of transcription. Our data indicate that mRNA reading frame can influence events at or near the site of gene transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:55:52