Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats
Autore:
Deng, AY; Dutil, J; Sivo, Z;
Indirizzi:
Hotel Dieu, CHUM, Res Ctr, Montreal, PQ H2W 1T8, Canada Hotel Dieu Montreal PQ Canada H2W 1T8 s Ctr, Montreal, PQ H2W 1T8, Canada
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 8, volume: 12, anno: 2001,
pagine: 612 - 616
SICI:
0938-8990(200108)12:8<612:UOMCTM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALT-SENSITIVE RATS; GENETIC-HYPERTENSION; GENOME SCAN; LINKAGE; STRAINS; CHROMOSOME-10; QTL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Deng, AY Hotel Dieu, CHUM, Res Ctr, 3840 Rue St Urbain, Montreal, PQ H2W 1T8, Canada Hotel Dieu 3840 Rue St Urbain Montreal PQ Canada H2W 1T8 , Canada
Citazione:
A.Y. Deng et al., "Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats", MAMM GENOME, 12(8), 2001, pp. 612-616

Abstract

A broad Chromosome (Chr) 10 region of the Dahl salt-sensitive (S) rat was shown by linkage and the use of congenic strains to contain a blood pressure (BP) quantitative trait locus (QTL). To further narrow down the region harboring the QTL, four congenic strains carrying smaller segments were made by replacing various segments of the S rats with the homologous segments ofthe Lewis (LEW) rats. The construction of these congenic strains was facilitated by a genome-wide marker screening. One congenic strain, assigned as S.L4, showed a BP-lowering effect, and the region harboring a BP QTL, designated QTL1, is localized to a segment of about 15 cM. Two other strains, assigned as S.L2 and S.L5, contained an overlapping segment, and both showed a BP-lowering effect. In contrast, the fourth congenic strain, assigned as S.L1, contained a smaller and shared fragment with S.L2 and S.L5, but it did not have a BP-lowering effect. Deducing from the segment in common in S.L2 and S.L5, and not shared between S.L1 and both congenic strains S.L2 and S.L5, the region harboring a QTL, designated as QTL2, was narrowed to about12 cM. The current work showed the general applicability of the 'speed congenic' approach to map and fine-map BP QTL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:19