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Titolo:
Age-related reduction of extrastriatal dopamine D-2 receptor measured by PET
Autore:
Inoue, M; Suhara, T; Sudo, Y; Okubo, Y; Yasuno, F; Kishimoto, T; Yoshikawa, K; Tanada, S;
Indirizzi:
Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 Inage Ku, Chiba 2638555, Japan Tokyo Med & Dent Univ, Fac Med, Sect Clin Physiol, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Nara Med Univ, Dept Psychiat, Kashihara, Nara 6348523, Japan Nara Med Univ Kashihara Nara Japan 6348523 Kashihara, Nara 6348523, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 9, volume: 69, anno: 2001,
pagine: 1079 - 1084
SICI:
0024-3205(20010720)69:9<1079:AROEDD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; C-11 RACLOPRIDE; DEPENDENT DECLINE; DELIRIUM; BINDING; DENSITY; D1;
Keywords:
aging; extrastriatal regions; dopamine D-2 receptor; [C-11]FLB 457; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Suhara, T Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, 4-9-1 Anagawa, Chiba 2638555, Japan Natl Inst Radiol Sci 4-9-1 Anagawa Chiba Japan 2638555 5, Japan
Citazione:
M. Inoue et al., "Age-related reduction of extrastriatal dopamine D-2 receptor measured by PET", LIFE SCI, 69(9), 2001, pp. 1079-1084

Abstract

Although the aging effect of dopamine D-2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D-2 receptor has not been fully examined. Since the density of extrastriatal dopamine D-2receptor is very low, suitable ligands are limited. In this study, we used[C-11]FLB 457 to quantify the extrastriatal dopamine D-2 receptor in the living human brain. Twenty-seven healthy male subjects aged from 21 to 82 years participated in the positron emission tomography study. Extrastriatal [C-11]FLB 457 binding was quantified with a reference tissue model using cerebellum as a reference region. Binding potentials corresponding to Bmax /Kdwere used to evaluate age-related change. We found age-related decreases of D-2 receptor binding in all measured extrastriatal regions. The decrease of D-2 receptor binding was 13.8% per decade in frontal cortex, 12.0% in temporal cortex, 13.4% in parietal cortex, 12.4% in occipital cortex, 12.2% in hippocampus, and 4.8% in thalamus. These findings suggest that the amounts of D-2 receptor declines in all brain regions as part of the normal agingprocess. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:56:06