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Titolo:
Differences between the tolerance characteristics of two anticonvulsant benzodiazepines in the amygdaloid-kindled rat
Autore:
Amano, K; Katsuragi, S; Takamatsu, J; Ogata, A; Miyazaki, C; Deshimaru, M; Miyakawa, T;
Indirizzi:
Kikuchi Natl Hosp, Dept Psychiat, Kikuchi, Kumamoto 8611116, Japan KikuchiNatl Hosp Kikuchi Kumamoto Japan 8611116 Kumamoto 8611116, Japan Kikuchi Natl Hosp, Dept Clin Res, Kikuchi, Kumamoto 8611116, Japan KikuchiNatl Hosp Kikuchi Kumamoto Japan 8611116 Kumamoto 8611116, Japan Kumamoto Univ, Fac Educ, Kumamoto 8600862, Japan Kumamoto Univ Kumamoto Japan 8600862 , Fac Educ, Kumamoto 8600862, Japan Kumamoto Univ, Sch Med, Dept Psychiat, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 t Psychiat, Kumamoto 8600811, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 9, volume: 69, anno: 2001,
pagine: 1049 - 1055
SICI:
0024-3205(20010720)69:9<1049:DBTTCO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIPOTASSIUM CLORAZEPATE; DIAZEPAM; SEIZURES; CLONAZEPAM; RECEPTORS; BINDING;
Keywords:
tolerance; benzodiazepines; dipotassium clorazepate; diazepam; functional;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Amano, K Kumamoto Natl Hosp, Dept Psychiat, Kumamoto 8600008, Japan Kumamoto Natl Hosp Kumamoto Japan 8600008 mamoto 8600008, Japan
Citazione:
K. Amano et al., "Differences between the tolerance characteristics of two anticonvulsant benzodiazepines in the amygdaloid-kindled rat", LIFE SCI, 69(9), 2001, pp. 1049-1055

Abstract

The characteristics of the development of tolerance to the anticonvulsant effects of chronic treatment by dipotassium clorazepate and diazepam using amygdaloid-kindled rats were investigated. Dipotassium clorazepate (5 mg/kg) or diazepam (5 mg/kg) were intraperitoneally administered for 10 consecutive days. Tolerance to the anticonvulsant effect of dipotassium clorazepatedeveloped in seizure stage on day 6, after-discharge duration on day 7 andseizure latency on day 4. In contrast, tolerance to the effects of diazepam developed more rapidly in seizure stage on day 4, after-discharge duration on day 4 and seizure latency on day 3. Thus tolerance to the anticonvulsive effect of dipotassium clorazepate developed relatively slower than that to diazepam. All rats had stage 5 convulsions 24 hr after cessation of the administration of dipotassium clorazepate and diazepam. Concomitant determinations of plasma concentrations of the main metabolite of dipotassium clorazepate and diazepam, desmethyldiazepam, showed no statistical difference during treatment, suggesting that the developed tolerance was not metabolic but functional. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 28/11/20 alle ore 21:30:37