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Titolo:
Is myelodysplastic related acute myelogenous leukemia a distinct entity from de novo acute myelogenous leukemia? Potential for targeted therapies
Autore:
Rosenfeld, C; Kantarjian, H;
Indirizzi:
Texas Oncol PA, Dallas, TX USA Texas Oncol PA Dallas TX USATexas Oncol PA, Dallas, TX USA
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 41, anno: 2001,
pagine: 493 - 500
SICI:
1042-8194(200105)41:5-6<493:IMRAML>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; SOUTHWEST-ONCOLOGY-GROUP; LUNG-RESISTANCE PROTEIN; TUMOR-SUPPRESSOR GENE; NITRIC-OXIDE SYNTHASE; BONE-MARROW CELLS; MULTIDRUG-RESISTANCE; HEMATOLOGICAL MALIGNANCIES; CLINICAL-SIGNIFICANCE; DISEASE PROGRESSION;
Keywords:
MDS; myelodysplastic syndromes; AML; de novo AML therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenfeld, C Suite D400 7777 Forest Lane, Dallas, TX 75230 USA Suite D4007777 Forest Lane Dallas TX USA 75230 TX 75230 USA
Citazione:
C. Rosenfeld e H. Kantarjian, "Is myelodysplastic related acute myelogenous leukemia a distinct entity from de novo acute myelogenous leukemia? Potential for targeted therapies", LEUK LYMPH, 41(5-6), 2001, pp. 493-500

Abstract

Acute myelogenous leukemia (AML) can be separated by whether the presentation was proceeded by a myelodysplastic (MDS related AML) or developed de novo (dAML), Clinically, MDS related AML (mAML) has been considered to have aworse prognosis that dAML. The objective of this literature review was to identify unique biologic features of mAML, Compared to dAML, mAML is characterized by an altered immunophenotype (increased frequency of CD34, CD11b and CD25), lack of leukemic progenitor cell suppression due to TGF beta1, increased bcl-2 expression, presence of inducible nitric oxide synthase, lower levels or mrp transcripts and increased expression of p53. Possible interpretations of these differences between mAML and dAML are presented. Implications for mAML directed therapy are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 16:05:42