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Titolo:
Biochemical profile of idiopathic uric acid nephrolithiasis
Autore:
Pak, CYC; Sakhaee, K; Peterson, RD; Poindexter, JR; Frawley, WH;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Mineral Metab & Clin Res, Dallas, TX 75390 USAUniv Texas Dallas TX USA 75390 ral Metab & Clin Res, Dallas, TX 75390 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 2, volume: 60, anno: 2001,
pagine: 757 - 761
SICI:
0085-2538(200108)60:2<757:BPOIUA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STONE FORMATION; CALCIUM;
Keywords:
urate stones; gout; hyperuricemia; hypertriglyceridemia; stone-former; renal ammoniagenesis; primary gout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Pak, CYC Univ Texas, SW Med Ctr, Ctr Mineral Metab & Clin Res, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TXUSA 75390 TX 75390 USA
Citazione:
C.Y.C. Pak et al., "Biochemical profile of idiopathic uric acid nephrolithiasis", KIDNEY INT, 60(2), 2001, pp. 757-761

Abstract

Background. The objective of this study was to elucidate a biochemical profile of patients with idiopathic uric acid nephrolithiasis, without secondary causes (such as dehydration or diarrhea). Study subjects comprised 56 patients with idiopathic uric acid nephrolithiasis (UA stone group) who underwent a full outpatient evaluation. The control group was composed of 54 with absorptive hypercalciuria and 2 normal subjects, matched with the UA stone group according to age, body mass index, and gender. Methods. Urinary pH and ammonium and serum and urinary uric acid were measured. The fractional excretion of urate was calculated. Results. Compared with the control group, the UA stone group had a significantly higher serum uric acid and significantly lower urinary uric acid, pH(5.34 +/- 0.23 vs. 6.17 +/- 0.36, P < 0.001), and fractional excretion of urate (0.052 +/- 0.028 vs. 0.080 +/- 0.029, P < 0.001), but individual values overlapped considerably between the two groups. Discriminant analysis ofthe relationship between urinary pH and fractional excretion of urate yielded a "discriminant score," which provided a much better separation betweenthe two groups, with a correct classification in 95.5% of subjects. In contrast, urinary ammonium, citrate, sulfate, and potassium did not differ between two groups. Conclusions. In idiopathic uric acid nephrolithiasis, urinary pH and fractional excretion of urate are significantly lower than in control subjects, suggestive of defects in urinary acidification and urate excretion. Since these impairments are believed to be associated with primary gout, the underlying disturbance in idiopathic uric acid nephrolithiasis may be primary gout.

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Documento generato il 18/01/20 alle ore 07:36:40