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Titolo:
Renal potassium channels: Function, regulation, and structure
Autore:
Giebisch, G;
Indirizzi:
Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 r & Mol Physiol, New Haven, CT 06520 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 2, volume: 60, anno: 2001,
pagine: 436 - 445
SICI:
0085-2538(200108)60:2<436:RPCFRA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
THICK ASCENDING LIMB; CORTICAL COLLECTING DUCT; PROXIMAL TUBULE CELLS; OPOSSUM KIDNEY-CELLS; PROTEIN-KINASE-A; MAXI K+ CHANNELS; APICAL MEMBRANE; BASOLATERAL MEMBRANE; GENETIC-HETEROGENEITY; INTRACELLULAR PH;
Keywords:
transport; K channels; Bartter's syndrome; volume regulation; cell-negative potential; thick ascending limb of Henle's loop;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Giebisch, G Yale Univ, Sch Med, Dept Cellular & Mol Physiol, 333 Cedar St,New Haven, CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 en, CT 06520 USA
Citazione:
G. Giebisch, "Renal potassium channels: Function, regulation, and structure", KIDNEY INT, 60(2), 2001, pp. 436-445

Abstract

Many transport functions in renal tubules depend on potassium (K) channels. Not only does K secretion and the maintenance of external K balance depend on K channel activity in principal tubule cells, but K channels also regulate cell volume, they are an integral party of cell function in all tubulecells because of their key role in the generation of the cell-negative electrical7 potential that affects the transmembrane movement of many charged solutes. Moreover, the recycling of K across the apical membrane of the thick ascending limb (TAL) plays an important role in the control of NaCl reabsorption in this tubule segment. Significant progress in our understanding of the structure and function of renal K channels has become possible by combining several strategies. These include transport studies in single tubules, application of the patch-clamp technique for exploring the properties of single K channels in native tubules and the cloning, and expression of diverse K channels of renal origin. Insights from these investigations promise to provide a deeper understanding of the mechanism by which K channels participate in many diverse tubule functions.

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Documento generato il 28/09/20 alle ore 14:34:44