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Titolo:
Retroviral splicing suppressor requires three nonconsensus uridines in a 5' splice site-like sequence
Autore:
Paca, RE; Hibbert, CS; OSullivan, CT; Beemon, KL;
Indirizzi:
Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA Johns Hopkins UnivBaltimore MD USA 21218 t Biol, Baltimore, MD 21218 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 16, volume: 75, anno: 2001,
pagine: 7763 - 7768
SICI:
0022-538X(200108)75:16<7763:RSSRTN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROUS-SARCOMA VIRUS; SMALL NUCLEAR RIBONUCLEOPROTEIN; NEGATIVE REGULATOR; INTRONIC SEQUENCES; UNSPLICED RNA; ELEMENT; U1; ACCUMULATION; SNRNP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Beemon, KL Johns Hopkins Univ, Dept Biol, 3400 N Chrles St, Baltimore, MD 21218 USA Johns Hopkins Univ 3400 N Chrles St Baltimore MD USA 21218 USA
Citazione:
R.E. Paca et al., "Retroviral splicing suppressor requires three nonconsensus uridines in a 5' splice site-like sequence", J VIROLOGY, 75(16), 2001, pp. 7763-7768

Abstract

Rous sarcoma virus RNA contains a negative regulator of splicing (NRS) element that aids in maintenance of unspliced RNA. The NRS binds U1 snRNA at asequence that deviates from the 5 ' splice site consensus by substitution of U's for A's at three positions: -2, +3, and +4. All three of these U's are important for NRS-mediated splicing suppression. Substitution of a single nonconsensus C or G at any of these sites diminished NRS activity, whereas substitution of a single A generated a preferred 5 ' splice site within the NIRS.

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Documento generato il 26/09/20 alle ore 11:49:26