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Titolo:
GLUTATHIONE AND NITRIC-OXIDE CONCENTRATIONS IN GLUTAMINE-INFUSED RABBITS WITH INTESTINAL ISCHAEMIA REPERFUSION/
Autore:
BASOGLU M; YILDIRGAN I; AKCAY F; KIZILTUNC A; KAVAK I; OREN D;
Indirizzi:
ATATURK UNIV,SCH MED,DEPT GEN SURG ERZURUM TURKEY ATATURK UNIV,SCH MED,DEPT BIOCHEM ERZURUM TURKEY
Titolo Testata:
European journal of clinical chemistry and clinical biochemistry
fascicolo: 6, volume: 35, anno: 1997,
pagine: 415 - 419
SICI:
0939-4974(1997)35:6<415:GANCIG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-MUCOSAL INJURY; L-ARGININE; ISCHEMIA-REPERFUSION; RAT-LIVER; METABOLISM; RADICALS; NITRATE; DAMAGE; SHOCK; ROLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Basoglu et al., "GLUTATHIONE AND NITRIC-OXIDE CONCENTRATIONS IN GLUTAMINE-INFUSED RABBITS WITH INTESTINAL ISCHAEMIA REPERFUSION/", European journal of clinical chemistry and clinical biochemistry, 35(6), 1997, pp. 415-419

Abstract

Intestinal ischaemia/reperfusion causes formation of reactive oxygen intermediates which lead to mucosal cell injury. Glutathione, a scavenger of reactive oxygen intermediates, protects tissues from reactive oxygen intermediate-mediate cell injury. Nitric oxide is a lipophilic gas and its synthesis is stimulated by ischaemic conditions. In this experimental study, we aimed to investigate the role of i.v. L-glutamineinfusion on mucosal tissue glutathione and serum nitric oxide concentrations in intestinal ischaemia/reperfusion. External jugular vein of albino rabbits was cannulated with catheter and infused with normal saline at 4 ml/h. After 3 days, they were randomly divided into two maingroups. Group 1 (n = 30) received i.v. normal saline alone, group 2 (n = 30) received normal saline + 205 mmol/l glutamine at 4 ml/h for 24hours. Next, mucosal glutathione and serum nitric oxide concentrations were measured after 0, 30, 60 min of ischaemia/60 min of reperfusion. Basal glutathione concentrations were similar in normal saline aloneand normal saline + 205 mmol/l glutamine infusion groups (p > 0.05). At 30 and 60 min of ischaemia/60 min of reperfusion, glutathione concentrations were significantly lower in normal saline-infused rabbits compared to the normal saline + 205 mmol/l glutamine-infused rabbits (p < 0.05). In addition, serum nitric oxide concentrations were found to be significantly increased in rabbits 30 and 60 min after ischaemia/reperfusion when compared to mean basal nitric oxide concentrations obtained from control animals. However, the normal saline + 205 mmol/l glutamine group had lower serum nitric oxide concentrations than did the normal saline alone group. In conclusion, this study revealed that intestinal mucosal glutathione concentrations were significantly higher in glutamine-receiving rabbits than in non-receiving ones. Additionally, it was shown that nitric oxide concentrations increased in ischaemiaboth in normal saline alone and normal saline + 205 mmol/l glutamine receiving groups, while this increase in nitric oxide was more prominent in the normal saline alone group (p < 0.01). These findings show that glutamine supplementation may protect the small intestine from ischaemia/reperfusion injury and may play a regulatory role in the biosynthesis of nitric oxide.

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Documento generato il 15/07/20 alle ore 08:34:01