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Titolo:
Stability of HCV-RNA level and its lack of correlation with disease severity in asymptomatic chronic hepatitis C virus carriers
Autore:
Yeo, AET; Ghany, M; Conry-Cantilena, C; Melpolder, JC; Kleiner, DE; Shih, JWK; Hoofnagle, JH; Alter, HJ;
Indirizzi:
NIH, Warren Grant Magnuson Clin Ctr, Dept Transfus Med, Bethesda, MD 20892USA NIH Bethesda MD USA 20892 n Ctr, Dept Transfus Med, Bethesda, MD 20892USA NIDDKD, Liver Dis Sect, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 Liver Dis Sect, NIH, Bethesda, MD 20892 USA NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 256 - 263
SICI:
1352-0504(200107)8:4<256:SOHLAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; BLOOD MONONUCLEAR-CELLS; CHRONIC LIVER-DISEASE; LINE PROBE ASSAY; QUANTITATIVE-ANALYSIS; SERUM; QUANTIFICATION; GENOTYPES; INFECTION; TITER;
Keywords:
hepatitis C virus; liver histology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Alter, HJ NIH, Warren Grant Magnuson Clin Ctr, Dept Transfus Med, Bldg 10,Bethesda,MD 20892 USA NIH Bldg 10 Bethesda MD USA 20892 Bldg 10, Bethesda,MD 20892 USA
Citazione:
A.E.T. Yeo et al., "Stability of HCV-RNA level and its lack of correlation with disease severity in asymptomatic chronic hepatitis C virus carriers", J VIRAL HEP, 8(4), 2001, pp. 256-263

Abstract

This study examines the relationship between HCV-RNA levels and disease severity in 60 individuals with chronic hepatitis C virus infection. HCV-RNA levels were quantified by the branched DNA (bDNA) assay in 445 samples (median: eight samples per patient) obtained over a median of 40.4 months (95% confidence interval (CI): 37.0-42.5). The median log HCV-RNA level was 6.77(95% CI: 6.62-6.92) molecular equivalents/mL (MEQ/mL). The median log range of HCV-RNA levels in individual patients over the course of the study was0.89 (95% CI: 0.69-1.16). HCV-RNA level varied over time by less than one log in 62% of patients, by 1-1.5 logs in 22% and by greater than 1.5 logs in only 17%. Univariate analysis, revealed an inverse association between HCV-RNA levels and ALT levels (P=0.037). Univariate and logistic regression analysis showed no significant association between HCV-RNA levels and eitherthe degree of inflammation or fibrosis. In contrast, there was a significant positive association between alanine aminotransferase (ALT) levels and histological activity especially in individuals with ALTs> 100 IU/L. Hence, HCV-RNA levels: (i) almost always fell within the dynamic range of the bDNAassay; (ii) were stable in asymptomatic chronically infected patients, with only a small proportion of patients exceeding a range of 1.5 logs; (iii) did not correlate with either the extent of inflammation or degree of fibrosis. In contrast, there was a strong association between ALT level and the histological severity of liver disease.

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Documento generato il 19/01/20 alle ore 09:28:36