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Titolo:
Urinary cadmium elimination as a biomarker of exposure for evaluating a cadmium dietary exposure-biokinetics model
Autore:
Choudhury, H; Harvey, T; Thayer, WC; Lockwood, TF; Stiteler, WM; Goodrum, PE; Hassett, JM; Diamond, GL;
Indirizzi:
Syracuse Res Corp, N Syracuse, NY 13212 USA Syracuse Res Corp N Syracuse NY USA 13212 Corp, N Syracuse, NY 13212 USA US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA US EPA Cincinnati OH USA 45268 ironm Assessment, Cincinnati, OH 45268 USA SUNY Coll Environm Sci & Forestry, Syracuse, NY 13210 USA SUNY Coll Environm Sci & Forestry Syracuse NY USA 13210 use, NY 13210 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 5, volume: 63, anno: 2001,
pagine: 321 - 350
SICI:
1528-7394(20010706)63:5<321:UCEAAB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RESPONSE RELATIONSHIP; UNITED-STATES; BODY BURDEN; POPULATION; LEAD; PESTICIDES; CHEMICALS; ELEMENTS; FOOD; BETA-2-MICROGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Diamond, GL Syracuse Res Corp, 6225 Running Ridge Rd, N Syracuse, NY 13212USA Syracuse Res Corp 6225 Running Ridge Rd N Syracuse NY USA 13212
Citazione:
H. Choudhury et al., "Urinary cadmium elimination as a biomarker of exposure for evaluating a cadmium dietary exposure-biokinetics model", J TOX E H A, 63(5), 2001, pp. 321-350

Abstract

The Cadmium Dietary Exposure Model (CDEM) utilizes national survey data onfood cadmium concentrations and food consumption patterns to estimate dietary intakes in the U.S. population. The CDEM has been linked to a modification of the cadmium biokinetic model of Kjellstrom and Nordberg (KNM) to derive predictions of kidney and urinary cadmium that reflect U.S. dietary cadmium intake and related variability. Variability in dietary cadmium intake was propagated through the KNM using a Monte Carlo approach. The model predicts a mean peak kidney cadmium burden of approximately 3.5 mg and a 5th-95th percentile range of 2.2-5.1 mg in males. The corresponding peak renal cortex cadmium concentration in males is 15 mug/g wet cortex (10-22, 5th-95thpercentile). Predicted kidney cadmium levels in females were higher than males: 5.1 (3.3-7.6) mg total kidney, 29 (19-43) mug/g wet cortex. Predictedurinary cadmium in males and females agreed with empirical estimates basedon the NHANES III, with females predicted and observed to excrete approximately twice the amount of cadmium in urine than males. An explanation for the higher urinary cadmium excretion in females is proposed that is consistent with the NHANES III data as well as experimental studies in humans and animals. remakes may absorb a larger fraction of ingested dietary cadmium than males, and this difference may be the result of lower iron body stores in females compared to males. This would suggest that females may be at greater risk of developing cadmium toxicity than males. The predicted 5th-95th percentile values for peak kidney cadmium burden are approximately 60% of the peak kidney burden (8-11 mg) predicted for a chronic intake at the U.S. Environmental Protection Agency (EPA) chronic reference dose of 1 mug/kg-d.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:49:33