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Titolo:
SPECT imaging of the dopamine transporter with [I-123]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction
Autore:
Sakakibara, R; Shinotoh, H; Uchiyama, T; Yoshiyama, M; Hattori, T; Yamanishi, T;
Indirizzi:
Chiba Univ, Sch Med, Dept Neurol, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 ept Neurol, Chuo Ku, Chiba 2608670, Japan Chiba Univ, Sch Med, Dept Urol, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Dept Urol, Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 187, anno: 2001,
pagine: 55 - 59
SICI:
0022-510X(20010615)187:1-2<55:SIOTDT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SYSTEM ATROPHY; I-123 BETA-CIT; STRIATONIGRAL DEGENERATION; SUPRANUCLEAR PALSY; TRACT DYSFUNCTION; CHANGES RELATE; BINDING; BRAIN; AGE; PET;
Keywords:
Parkinson's disease; urinary dysfunction; dopamine transporter; single-photon emission computed tomography (SPECT); [I-123]-beta-CIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sakakibara, R Chiba Univ, Sch Med, Dept Neurol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 2608670, Japan
Citazione:
R. Sakakibara et al., "SPECT imaging of the dopamine transporter with [I-123]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction", J NEUR SCI, 187(1-2), 2001, pp. 55-59

Abstract

We studied a correlation of urinary dysfunction with nigrostriatal dopaminergic deficit in Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) imaging of dopamine transporter with [I-123]-2 beta -carbomethoxy-3 beta-(4-iodophenyl) (beta -CIT). Eleven patients were enrolled in the study, including four men and seven women, with a mean age of 64 years. Seven patients had urinary symptoms 1-5 years after the onset of motor disorder, which included nighttime frequency in six, urinary retardation in four, daytime frequency in one and urge urinary incontinence in one. Using a SPECT camera, the ratio specific to nondisplaceable [I-123]-beta -CIT uptake, designated as 'striatal V3' was obtained in the caudate, anterior and posterior putamen 24 h after the tracer injection. The striatal V3 was compared in patients with and without urinary dysfunction, and between men and women, using unpaired Student's t-test. Correlation of motor dysfunctionand duration of illness with urinary dysfunction, was also analyzed. In the patients, there was a reduction of [I-123]-beta -CIT binding in the striatum on both sides, particularly in the putamen contralateral to the affected body side. The striatal V3 of the caudate (p < 0.01, Rt; p < 0.05, Lt), anterior putamen (p < 0.05, Rt) and posterior putamen (p < 0.05, Rt) in patients with urinary dysfunction was significantly reduced than those without urinary dysfunction. No sex difference was seen in reduction of [I-123]-beta -CIT binding. Urinary dysfunction in PD was more common in patients with higher Unified Parkinson's Disease Rating Scale (UPDRS) score, higher Hoehn-Yahr grade, but not in those with longer duration of disease, although there was no statistical significance. It is likely that our results reflect the association of urinary dysfunction and degeneration of the nigrostriataldopaminergic cells in PD. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 08:24:28