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Titolo:
Angiotensin II and prostaglandin interactions on systemic and renal effects of L-NAME in humans
Autore:
Perinotto, P; Biggi, A; Carra, N; Orrico, A; Valmadre, G; DallAglio, P; Novarini, A; Montanari, A;
Indirizzi:
Univ Parma, Ist Patol Med, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 arma, Ist Patol Med, I-43100 Parma, Italy Univ Parma, Ist Semeiot Med, I-43100 Parma, Italy Univ Parma Parma ItalyI-43100 ma, Ist Semeiot Med, I-43100 Parma, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1706 - 1712
SICI:
1046-6673(200108)12:8<1706:AIAPIO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHESIS; SALT-SENSITIVE HYPERTENSION; SYNTHESIS INHIBITION; ENDOTHELIAL FUNCTION; VASCULAR RELAXATION; HEALTHY-SUBJECTS; L-ARGININE; BLOCKADE; HEMODYNAMICS; NATRIURESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Montanari, A Univ Parma, Ist Patol Med, Via Gramsci 14, I-43100 Parma, Italy Univ Parma Via Gramsci 14 Parma Italy I-43100 0 Parma, Italy
Citazione:
P. Perinotto et al., "Angiotensin II and prostaglandin interactions on systemic and renal effects of L-NAME in humans", J AM S NEPH, 12(8), 2001, pp. 1706-1712

Abstract

For investigation of whether interactions between prostaglandins and angiotensin Il modulate renal response to acute nitric oxide synthesis inhibition in humans, seven young volunteers who were kept on a 240-mM Na diet underwent four experiments with 90 min of infusion of 3.0 mug/kg.min(-1) NG-nitro-L-arginine methyl ester (L-NAME), each preceded by a 3-d treatment with placebo (PL), 50 mg of losartan (LOS), 75 to 125 mg of indomethacin (IND), or both drugs. Mean arterial pressure (MAP), GFR, effective renal plasma flow (ERPF), and Na excretion rate (UNaV) were measured at baseline and from 0to 45 min and 45 to 90 min of L-NAME infusion. After FL, L-NAME reduced GFR by 5% at 45 min (P < 0.05) and by 9% at 90 min (P < 0.001), ERPF by II to17% (P < 0.001), and UNaV by 28 to 45% (P < 0.001). MAP, unchanged at 45 min, rose by 5% (P < 0.001) at 90 min. LOS prevented presser but not renal effects of L-NAME. With L-NAME+IND, MAP rose even at 45 min (+5%; P < 0.001 versus baseline) with a 10% rise at 90 min (P < 0.001). Changes in GFR (-13to -20%), ERPF (-19 to -26%), and UNaV (-51 to -70%) were greater than those with L-NAME+PL or L-NAME+LOS (P < 0.05 to 0.001). With L-NAME+IND+LOS, MAP did not increase, and GFR, ERPF, and UNaV fell much less than with L-NAME+IND alone (P < 0.02 to 0.001) with no differences versus PL or LOS alone. Angiotensin II blockade does not affect renal changes caused by L-NAME butprevents their potentiation by prostaglandin inhibition. Thus, endogenous prostaglandins counteract renal actions of endogenous angiotensin II in Na-repleted humans even when nitric oxide synthesis is inhibited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:01:37