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Titolo:
Corticosteroids and cognition
Autore:
Belanoff, JK; Gross, K; Yager, A; Schatzberg, AF;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Psychiat, Stanford, CA 94305 USA Pacific Grad Sch Psychol, Palo Alto, CA 94303 USA Pacific Grad Sch Psychol Palo Alto CA USA 94303 , Palo Alto, CA 94303 USA
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 3, volume: 35, anno: 2001,
pagine: 127 - 145
SICI:
0022-3956(200105/06)35:3<127:CAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; CHRONIC PSYCHOSOCIAL STRESS; LONG-TERM POTENTIATION; CA3 PYRAMIDAL NEURONS; ALZHEIMERS-DISEASE; DECLARATIVE MEMORY; CUSHINGS-DISEASE; CORTISOL-LEVELS; DEPRESSED-PATIENTS; RAT-BRAIN;
Keywords:
cognition; glucocorticoids; cortisol; hippocampus; memory; glucocorticoid receptor antagonists;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Gross, K 3883 18th St, San Francisco, CA 94114 USA 3883 18th St San Francisco CA USA 94114 Francisco, CA 94114 USA
Citazione:
J.K. Belanoff et al., "Corticosteroids and cognition", J PSYCH RES, 35(3), 2001, pp. 127-145

Abstract

The brain is a major target organ for corticosteroids. It has been observed that excessive circulatory levels of endogenous and exogenous corticosteroids are frequently associated with cognitive impairment in a wide variety of clinical disease states. Cognition and low levels of corticosteroids have been less well studied. In this paper we review the literature on glucocorticosteroid effects on cognition and delineate specific functions that appear to be causally affected. We draw a possible connection to specific areas of brain perturbation, including the hippocampus and frontal lobe regions. The possibility that cognitive dysfunction caused by glucocorticoids can be pharmacologically managed is introduced. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:56:31