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Titolo:
S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine
Autore:
Millan, MJ; Dekeyne, A; Papp, M; La Rochelle, CD; Macsweeny, C; Peglion, JL; Brocco, M;
Indirizzi:
Inst Rech Servier, Ctr Rech Croissy, Dept Psychopharmacol, Paris, France Inst Rech Servier Paris France ssy, Dept Psychopharmacol, Paris, France Inst Rech Servier, Ctr Rech Suresnes, Chem Dept B, Paris, France Inst RechServier Paris France ech Suresnes, Chem Dept B, Paris, France Polish Acad Sci, Inst Pharmacol, Krakow, Poland Polish Acad Sci Krakow Poland Acad Sci, Inst Pharmacol, Krakow, Poland Biotrial, Rennes, France Biotrial Rennes FranceBiotrial, Rennes, France
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 2, volume: 298, anno: 2001,
pagine: 581 - 591
SICI:
0022-3565(200108)298:2<581:SANLAB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; FORCED SWIMMING TEST; ANTIDEPRESSANT DRUGS; ANIMAL-MODELS; AGGRESSIVE-BEHAVIOR; REUPTAKE INHIBITOR; UPTAKE BLOCKERS; DEPRESSION; RATS; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Millan, MJ Inst Rech Servier, Ctr Rech Croissy, Dept Psychopharmacol, 125 Chemin Ronde, F-78290 Croissy Seine, France Inst Rech Servier 125 Chemin Ronde Croissy Seine France F-78290
Citazione:
M.J. Millan et al., "S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine", J PHARM EXP, 298(2), 2001, pp. 581-591

Abstract

Reflecting its potent inhibition of serotonin (5-HT) reuptake (accompanying paper), S33005 blocked spontaneous tail-flicks induced by parachloroamphetamine in rats. This action was mimicked by the 5-HT reuptake inhibitor, citalopram, and the 5-HT/norepinephrine (NE) reuptake inhibitor, venlafaxine,whereas the preferential NE reuptake inhibitor, reboxetine, was inactive. Consistent with its less potent interaction with NE transporters, higher doses of S33005 attenuated induction of hypothermia by reserpine, an action mimicked by reboxetine and venlafaxine, whereas citalopram was ineffective. In mice, S33005 reduced immobility in forced-swim and tail-suspension procedures. It also inhibited marble-burying behavior and suppressed aggressive behavior between resident and intruder animals. In rats, S33005 generalizedto a discriminative stimulus elicited by citalopram and attenuated hypnotic-sedative actions of the alpha (2)-adrenoceptor agonist, S18616. For theseparameters, S33005 was a more potent agent (median, 1.2 mg/kg, s.c.) than venlafaxine, citalopram, reboxetine, or the tricyclic agent, clomipramine. Even at markedly higher doses (40.0-80.0 mg/kg, s.c.), S33005 little affected motor behavior. S33005 (10.0 mg/kg, s.c.) also increased responses in a learned helplessness paradigm in rats, whereas venlafaxine was ineffective. Finally, in a rat chronic mild-stress model, S33005 dose- (2.5-40.0 mg/kg)and time- (2-5 weeks) dependently enhanced sucrose consumption. Venlafaxine was likewise active in this procedure. In conclusion, in line with its inhibition of 5-HT and (less potently) NE reuptake, S33005 is active in a broad range of models suggestive of antidepressant activity. It exerts its actions more potently than venlafaxine and clomipramine, and its overall profile is distinct from those of citalopram and reboxetine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:11:25