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Titolo:
Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: Possible role for dendritically released dopamine
Autore:
Ranaldi, R; Wise, RA;
Indirizzi:
CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA CUNY Queens Coll Flushing NY USA 11367 pt Psychol, Flushing, NY 11367 USA NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ral Res Program, NIH, Baltimore, MD 21224 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: 5841 - 5846
SICI:
0270-6474(20010801)21:15<5841:BODDRI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE RATIO SCHEDULES; MEDIAL PREFRONTAL CORTEX; METHYL-D-ASPARTATE; NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA; BASAL GANGLIA; EXTRACELLULAR DOPAMINE; INTRAVENOUS COCAINE; SELF-STIMULATION; 5-HT2 RECEPTORS;
Keywords:
drug abuse; reinforcement; dendritic release; motivation; operant learning; progressive ratio schedule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Ranaldi, R CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA CUNY Queens Coll 65-30 Kissena Blvd Flushing NY USA 11367 7 USA
Citazione:
R. Ranaldi e R.A. Wise, "Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: Possible role for dendritically released dopamine", J NEUROSC, 21(15), 2001, pp. 5841-5846

Abstract

This study was designed to assess the involvement of D1 dopamine actions in the ventral tegmental area (VTA) on intravenous cocaine self-administration. Rats were trained to self-administer intravenous injections of cocaine (1.0 mg/kg per injection) on a fixed-ratio 1 (FR-1) schedule or a progressive ratio (PR) schedule of reinforcement and then were tested under the influence of bilateral VTA injections of the D1 dopamine receptor antagonist SCH 23390 or the 5-HT2 receptor antagonist ketanserin. SCH 23390 increased cocaine self-administration on the FR-1 schedule but decreased it on the PR schedule. Injections of ketanserin were ineffective, as were injections of SCH 23390 in a site 1 mm dorsal or 1 mm rostral to the effective VTA site. These data suggest a role for dendritically released dopamine, presumably acting through D1 receptors located on the axons of GABAergic or glutamatergic inputs to the VTA, in the effectiveness of cocaine reward.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:44:56