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Titolo:
Synaptic heterogeneity and stimulus-induced modulation of depression in central synapses
Autore:
Hunter, JD; Milton, JG;
Indirizzi:
Univ Chicago, Dept Neurol, Comm Computat Neurosci, Chicago, IL 60615 USA Univ Chicago Chicago IL USA 60615 omputat Neurosci, Chicago, IL 60615 USA Univ Chicago, Comm Neurobiol, Chicago, IL 60615 USA Univ Chicago Chicago IL USA 60615 , Comm Neurobiol, Chicago, IL 60615 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: 5781 - 5793
SICI:
0270-6474(20010801)21:15<5781:SHASMO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL BIPOLAR CELLS; NEUROMUSCULAR-JUNCTION; QUANTITATIVE DESCRIPTION; HIPPOCAMPAL SYNAPSES; TRANSMITTER RELEASE; CLIMBING FIBER; NEURONS; EXOCYTOSIS; RECEPTORS; APLYSIA;
Keywords:
central cholinergic synapses; Aplysia; depletion; desensitization; availability; optimization; model; stimulus history effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Milton, JG Univ Chicago, Dept Neurol, Comm Computat Neurosci, 5841 S Maryland Ave, Chicago, IL 60615 USA Univ Chicago 5841 S Maryland Ave Chicago IL USA 60615 60615 USA
Citazione:
J.D. Hunter e J.G. Milton, "Synaptic heterogeneity and stimulus-induced modulation of depression in central synapses", J NEUROSC, 21(15), 2001, pp. 5781-5793

Abstract

Short-term plasticity is a pervasive feature of synapses. Synapses exhibitmany forms of plasticity operating over a range of time scales. We developan optimization method that allows rapid characterization of synapses withmultiple time scales of facilitation and depression. Investigation of paired neurons that are postsynaptic to the same identified interneuron in the buccal ganglion of Aplysia reveals that the responses of the two neurons differ in the magnitude of synaptic depression. Also, for single neurons, prolonged stimulation of the presynaptic neuron causes stimulus-induced increases in the early phase of synaptic depression. These observations can be described by a model that incorporates two availability factors, e.g., depletable vesicle pools or desensitizing receptor populations, with different time courses of recovery, and a single facilitation component. This model accurately predicts the responses to novel stimuli. The source of synaptic heterogeneity is identified with variations in the relative sizes of the two availability factors, and the stimulus-induced decrement in the early synaptic response is explained by a slowing of the recovery rate of one of the availability factors. The synaptic heterogeneity and stimulus-induced modifications in synaptic depression observed here emphasize that synaptic efficacy depends on both the individual properties of synapses and their past history.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:07:41