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Titolo:
Different requirements for protein synthesis in acquisition and extinctionof spatial preferences and context-evoked fear
Autore:
Lattal, KM; Abel, T;
Indirizzi:
Univ Penn, Dept Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Biol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: 5773 - 5780
SICI:
0270-6474(20010801)21:15<5773:DRFPSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; SPONTANEOUS-RECOVERY; POTENTIATED STARTLE; PREFRONTAL CORTEX; NMDA ANTAGONIST; COMPONENTS; INHIBITION; RETRIEVAL; RECEPTOR; BLOCKADE;
Keywords:
memory; extinction; protein synthesis; spatial learning; fear conditioning; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Abel, T Univ Penn, Dept Biol, 3740 Hamilton Walk, Philadelphia, PA 19104 USA Univ Penn 3740 Hamilton Walk Philadelphia PA USA 19104 A 19104 USA
Citazione:
K.M. Lattal e T. Abel, "Different requirements for protein synthesis in acquisition and extinctionof spatial preferences and context-evoked fear", J NEUROSC, 21(15), 2001, pp. 5773-5780

Abstract

Many molecular accounts of long-term memory storage postulate that the synthesis of new proteins is necessary for longterm changes in neuronal function. These experiments generally have examined the learning that occurs as associations are acquired between neutral and biologically important stimuli. Little is known about the importance of protein synthesis in the establishment of memories for extinction, which occurs as the relations establishedduring acquisition are severed. Extinction appears to be an active learning process that results in the formation of new memories rather than in the simple erasure or forgetting of memories from acquisition. Furthermore, under certain circumstances, extinction can result in long-term changes in behavior lasting for days to weeks. Here we show that although memories for the acquisition of spatial and contextual learning required protein synthesis, memories for extinction formed in the absence of protein synthesis. Theseresults suggest that acquisition and extinction are mediated by distinct molecular mechanisms and that long-term memories can form in the absence of protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:50:42