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Titolo:
Segregation and convergence of information flow through the cortico-subthalamic pathways
Autore:
Kolomiets, BP; Deniau, JM; Mailly, P; Menetrey, A; Glowinski, J; Thierry, AM;
Indirizzi:
Coll France, Chaire Neuropharmacol, INSERM, U114, F-75231 Paris 05, FranceColl France Paris France 05 acol, INSERM, U114, F-75231 Paris 05, France Univ Paris 06, CNRS, NPA NSI, F-75230 Paris, France Univ Paris 06 Paris France F-75230 CNRS, NPA NSI, F-75230 Paris, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: 5764 - 5772
SICI:
0270-6474(20010801)21:15<5764:SACOIF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGRA PARS RETICULATA; MEDIAL PREFRONTAL CORTEX; BASAL GANGLIA; HORSERADISH-PEROXIDASE; CEREBRAL-CORTEX; AFFERENT CONNECTIONS; COMBINED RETROGRADE; VENTRAL PALLIDUM; GLOBUS-PALLIDUS; RAT;
Keywords:
prefrontal cortex; motor cortex; auditory cortex; striatum; subthalamus; basal ganglia; rat; ketamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Thierry, AM Coll France, Chaire Neuropharmacol, INSERM, U114, 11 Pl M Berthelot, F-75231 Paris 05, France Coll France 11 Pl M Berthelot Paris France05 aris 05, France
Citazione:
B.P. Kolomiets et al., "Segregation and convergence of information flow through the cortico-subthalamic pathways", J NEUROSC, 21(15), 2001, pp. 5764-5772

Abstract

Cortico-basal ganglia circuits are organized in parallel channels. Information flow from functionally distinct cortical areas remains segregated within the striatum and through its direct projections to basal ganglia output structures. Whether such a segregation is maintained in trans-subthalamic circuits is still questioned. The effects of electrical stimulation of prefrontal, motor, and auditory cortex were analyzed in the subthalamic nucleus as well as in the striatum of anesthetized rats. In the striatum, cells (n = 300) presenting an excitatory response to stimulation of these cortical areas were located in distinct striatal territories, and none of the cells responded to two cortical stimulation sites. In the subthalamic nucleus, both prefrontal and motor cortex stimulations induced early and late excitatory responses as a result of activation of the direct cortico-subthalamic pathway and of the indirect cortico-striato-pallido-subthalamic pathway, respectively. Stimulation of the auditory cortex, which does not send direct projection to the subthalamic nucleus, induced only late excitatory responses. Among the subthalamic responding cells (n = 441), a few received both prefrontal and motor cortex (n = 19) or prefrontal and auditory cortex (n = 10)excitatory inputs, whereas a larger number of cells were activated from both motor and auditory cortices (n = 48). The data indicate that the segregation of cortical information flow originating from prefrontal, motor, and auditory cortices that occurred in the striatum is only partly maintained inthe subthalamic nucleus. It can be proposed that the existence of specificpatterns of convergence of information flow from these functionally distinct cortical areas in the subthalamic nucleus allows interactions between parallel channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:57:26