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Titolo:
Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation
Autore:
Waltereit, R; Dammermann, B; Wulff, P; Scafidi, J; Staubli, U; Kauselmann, G; Bundman, M; Kuhl, D;
Indirizzi:
Zentrum Mol Neurobiol Hamburg, Inst Neurale Signalverarbeitung, D-20246 Hamburg, Germany Zentrum Mol Neurobiol Hamburg Hamburg Germany D-20246 6 Hamburg, Germany NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: 5484 - 5493
SICI:
0270-6474(20010801)21:15<5484:AMIBCA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; ELEMENT-BINDING PROTEIN; TISSUE-PLASMINOGEN ACTIVATOR; C-FOS EXPRESSION; MESSENGER-RNA; DENTATE GYRUS; CYCLIC-AMP; RAT-BRAIN; ACETYLCHOLINE-RECEPTORS;
Keywords:
plasticity; long-term memory; hippocampus; LTP; gene induction; Arg3.1; Arc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhl, D Zentrum Mol Neurobiol Hamburg, Inst Neurale Signalverarbeitung, Martinistr52, D-20246 Hamburg, Germany Zentrum Mol Neurobiol Hamburg Martinistr 52 Hamburg Germany D-20246
Citazione:
R. Waltereit et al., "Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation", J NEUROSC, 21(15), 2001, pp. 5484-5493

Abstract

Long-term potentiation (LTP) is a cellular model for persistent synaptic plasticity in the mammalian brain. Like several forms of memory, long-lasting LTP requires cAMP-mediated activation of protein kinase A (PKA) and is dependent on gene transcription. Consequently, activity-dependent genes such as c-fos that contain cAMP response elements (CREs) in their 5' regulatory region have been studied intensely. More recently, arg3.1/ arc became of interest, because after synaptic stimulation, arg3.1/arc mRNA is rapidly induced and distributed to dendritic processes and may be locally translated there to facilitate synapse-specific modifications. However, to date nothing is known about the signaling mechanisms involved in the induction of this gene. Here we report that arg3.1/arc is robustly induced with LTP stimulation even at intensities that are not sufficient to activate c-fos expression. Unlike c-fos, the 5' regulatory region of arg3.1/arc does not contain a CRE consensus sequence and arg3.1/arc is unresponsive to cAMP in NIH3T3 and Neuro2a cells. However, in PC12 cells and primary cultures of hippocampal neurons, arg3.1/arc can be induced by cAMP and calcium. This induction requires the activity of PKA and mitogen-activated protein kinase, suggesting a neuron-specific pathway for the activation of arg3.1/arc expression.

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Documento generato il 31/03/20 alle ore 18:55:18