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Titolo:
Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei
Autore:
Gauck, V; Thomann, M; Jaeger, D; Borst, A;
Indirizzi:
Max Planck Soc, Friedrich Miescher Lab, D-72076 Tubingen, Germany Max Planck Soc Tubingen Germany D-72076 r Lab, D-72076 Tubingen, Germany Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ry Univ, Dept Biol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 21, anno: 2001,
pagine: NIL_11 - NIL_14
SICI:
0270-6474(20010801)21:15<NIL_11:SDOLAH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL PYRAMIDAL NEURONS; PURKINJE-CELL ACTIVITY; THALAMIC RELAY CELLS; CA2+ CHANNELS; RAT; DENDRITES; INVITRO;
Keywords:
calcium imaging; low-voltage-activated calcium current; high-voltage-activated calcium current; dendritic integration; subcellular compartmentalization; cerebellar nuclei;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gauck, V Univ Tubingen, Dept Neurol Cognit Neurol, Morgenstelle 15, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 15 Tubingen Germany D-72076, Germany
Citazione:
V. Gauck et al., "Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei", J NEUROSC, 21(15), 2001, pp. NIL_11-NIL_14

Abstract

The spatial distribution of low-voltage-activated (LVA) and high-voltage-activated (HVA) barium currents was investigated in neurons of the deep cerebellar nuclei (DCN) by combining barium imaging with voltage clamp. The current-induced fluorescence signal (DeltaF/F) of the HVA current was five times higher then the LVA-induced signal at the soma, but both signals were approximately equal in size in distant dendrites. This position-dependent shift of DeltaF/F indicates a non-uniform distribution of the underlying calcium channels. The higher weight of the LVA signal in the dendrites suggests that the LVA might be of particular relevance for the dendritic integrationof synaptic inputs.

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Documento generato il 09/04/20 alle ore 07:41:39