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Titolo:
Ultrasonic assessment of physiological echo-contrast agent distribution inbrain parenchyma with transient response second harmonic imaging
Autore:
Postert, T; Federlein, J; Rose, J; Przuntek, H; Weber, S; Buttner, T;
Indirizzi:
Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, D-44791 Bochum, Germany RuhrUniv Bochum Bochum Germany D-44791 Neurol, D-44791 Bochum, Germany Schering AG, D-1000 Berlin, Germany Schering AG Berlin Germany D-1000Schering AG, D-1000 Berlin, Germany
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 1, volume: 11, anno: 2001,
pagine: 18 - 24
SICI:
1051-2284(200101)11:1<18:UAOPEA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL PERFUSION; ISCHEMIC STROKE; WEIGHTED MRI; BLOOD-FLOW; MICROBUBBLES; ECHOCARDIOGRAPHY; VISUALIZATION; INJECTION;
Keywords:
harmonic imaging; echo-contrast agents; transcranial ultrasound; neurosonology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Postert, T Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Gudrunstr 56, D-44791 Bochum, Germany Ruhr Univ Bochum Gudrunstr 56 Bochum Germany D-44791 , Germany
Citazione:
T. Postert et al., "Ultrasonic assessment of physiological echo-contrast agent distribution inbrain parenchyma with transient response second harmonic imaging", J NEUROIMAG, 11(1), 2001, pp. 18-24

Abstract

Objectives. The present study was designed to provide normal data of transient response second harmonic imaging (TRSHI) examinations of cerebral echocontrast enhancement using different modes of electrocardiogram (ECG) gating and echo-contrast agent doses. Materials and Methods. Fifty-five patients were examined in an axial diencephalic plane of section using the transtemporal acoustic bone:window., TRSHI examinations (ECG gating: systolic, frame-rate once every 2 cardiac cycles = "basical instrument setting") could be performed in 50 individuals with adequate insonation conditions after application of 4 g of a galactose-based microbubbles suspension in a concentration of 400 mg/ml. For comparison, diastolic ECG gating (20 patients). cardiac-cycle triggering frequency of once every 2 seconds (15 patients), or anecho contrast agent dose of 2 g Levovist (R) (15 patients) were used. Analysis of peak intensities (Pls) and areas under the curve (AUCs) was done inposterior (region of interest [ROI]a) and anterior (ROIb) parts of the thalamus, in the lentiform nucleus (ROIc), and the white matter (ROId). Results. In 41 patients with basical instrument setting, characteristic time intensity curve (TIC) could be detected in all ROIs. in ROIa(90%) and ROIb (82%), focal contrast enhancement was most difficult to visualize, and in ROIc and ROId, characteristic TICs were observable in more than 90% of the examinations. Background subtracted Pls and AUCs were significantly higher in ROIc (mean Pi: 12.2 +/- 8 acoustic units [AUs]; mean AUG: 598.8 +/- ,451.1 AUx Cardiac cycles), and ROId (11.8 +/- 6.9;559.2 +/-: 404) as compared to ROIa (8.3 +/- 5.2; 368.9 +/- 242.7) and ROIb (7.1 +/- 4.7; 2982 +/- 199.1) (P < .0001). Values for corresponding examinations with a diastolic ECG gating and a cardiac cycle triggering frequency of once every 2 seconds were not different as compared to the basical instrument setting. A4 g Levovist dose increased the portion of typical TIC in ail ROIs. PI of 4 g examinationswere significantly higher in ROId and ROIb as compared to the 2 g examination. Conclusion, Our findings indicate that TRSHI allows noninvasive assessment of focal cerebral contrast enhancement in the majority of patients with adequate insonation conditions. This study provides data about normal quantitative and qualitative TRSHI values in patients without cerebrovascular diseases. A dose of 4 g Levovist is recommended in those individuals with inaccurate echo contrast enhancement using the 2 g dose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:43:31