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Titolo:
Temporal changes in brain volume and cognition in a randomized treatment trial of vascular dementia
Autore:
Broderick, JP; Gaskill, M; Dhawan, A; Khoury, JC;
Indirizzi:
Univ Cincinnati, Med Ctr, Dept Neurol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Neurol, Cincinnati, OH 45267 USA Univ Cincinnati, Med Ctr, Dept Neuroradiol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 oradiol, Cincinnati, OH 45267 USA Univ Cincinnati, Med Ctr, Dept Environm Hlth, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 nm Hlth, Cincinnati, OH 45267 USA Univ Toledo, Coll Engn, Dept Bioengn, Toledo, OH USA Univ Toledo Toledo OH USA oledo, Coll Engn, Dept Bioengn, Toledo, OH USA
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 1, volume: 11, anno: 2001,
pagine: 6 - 12
SICI:
1051-2284(200101)11:1<6:TCIBVA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; ACUTE STROKE; RESONANCE; MRI; LEUKOENCEPHALOPATHY; ABNORMALITIES; LUCENCIES; SCALE; CT;
Keywords:
vascular dementia; brain volumes; stroke; magnetic resonance imaging; randomized trial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Broderick, JP Univ Cincinnati, Med Ctr, Dept Neurol, 231 Bethesda Ave,ML 0525, Cincinnati, OH 45267 USA Univ Cincinnati 231 Bethesda Ave,ML 0525 Cincinnati OH USA 45267
Citazione:
J.P. Broderick et al., "Temporal changes in brain volume and cognition in a randomized treatment trial of vascular dementia", J NEUROIMAG, 11(1), 2001, pp. 6-12

Abstract

overtime by magnetic resonance imaging (MRI) as part of a randomized treatment trial of vascular dementia. Methods. Participants who met criteria forvascular dementia Underwent comprehensive neurological and neuropsychological testing on entrance, during, and at completion of the 1-year study. Forthose centers who had easily available MRI, MRI of the brain was to be performed on entry and completion of the study. Image analysis was performed on: all balanced and T2-weighted MR films to determine ventricular, sulcal, ischemic, and hemispheric brain volumes. Results, Of the 105 patients who met the criteria for vascular dementia, 40 had a baseline MR[ study that metprotocol requirements and was of excellent image quality. The baseline ventricular volume in these 40 patients with high-quality MR correlated with, most measures of cognitive and behavioral function; including the total Alzheimer's Disease Assessment Score (ADAS) (r = 0.51, P = .0024), as well as activities of daily living (r = 0.61, P = .0002). The baseline ischemic brain volume correlated well only with the gait and postural stability scale tr = 0.74, P = .009). Of the 40 participants, 25 had MRL studies at baselineand at completion of the study that were comparable and of excellent imagequality. For these 25 patients, the mean ventricular volumes increased by 9% over the study year (P = .001) and the mean ischemic brain volume increased by 18% (P = .01). Temporal changes in the sulcal: and nonischemic brainvolume did not reach significance. None of the 14 clinical score measures changed significantly between baseline and completion of the study in these25 patients. Conclusion. In summary, ventricular volume correlated well with cognitive measures in patients with vascular dementia and was a more sensitive marker for change during the study year than the clinical scales used in this study. This study also points out the practical limitations of brain imaging as a surrogate measure of clinical outcome in multicenter randomized treatment trials of brain disease.

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Documento generato il 29/03/20 alle ore 00:14:35