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Titolo:
Reproducibility of proton magnetic resonance spectroscopy imaging measurements of normal human hippocampus at 1.5 T: Clinical implications
Autore:
Maton, B; Londono, A; Sawrie, S; Knowlton, R; denHollander, J; Kuzniecky, R;
Indirizzi:
Univ Alabama, Epilepsy Ctr, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ilepsy Ctr, Birmingham, AL 35294 USA Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Neurol, Birmingham, AL 35294 USA Univ Alabama, Ctr Nucl Imaging Res, Birmingham, AL 35294 USA Univ AlabamaBirmingham AL USA 35294 maging Res, Birmingham, AL 35294 USA
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 2, volume: 11, anno: 2001,
pagine: 194 - 201
SICI:
1051-2284(200104)11:2<194:ROPMRS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; IN-VIVO; H-1 MRS; PRESURGICAL LOCALIZATION; ALZHEIMERS-DISEASE; HUMAN BRAIN; NORMALIZATION;
Keywords:
proton magnetic resonance spectroscopy; hippocampus; brain; reproducibility; N-acetylaspartate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kuzniecky, R Univ Alabama, Epilepsy Ctr, 1719 6th Ave S,CIRC 312, Birmingham, AL 35294 USA Univ Alabama 1719 6th Ave S,CIRC 312 Birmingham AL USA 35294
Citazione:
B. Maton et al., "Reproducibility of proton magnetic resonance spectroscopy imaging measurements of normal human hippocampus at 1.5 T: Clinical implications", J NEUROIMAG, 11(2), 2001, pp. 194-201

Abstract

The authors investigate the reproducibility of metabolite signals measuredwith proton magnetic resonance spectroscopy (H-1-MRS) acquired from the human hippocampus in controls and in a phantom. Two H-1-MRS studies separatedby 3 weeks were performed in 8 healthy volunteers and in a phantom. N-acetyl compounds (NA), choline (Ch), and creatine (Cr) peak areas and ratios were measured and compared using percentage variation, and Pearson Correlation Coefficient at the level of every voxel, the level of 1 hippocampus (5 voxels), and the level of 2 hippocampi (10 voxels). Sensitivity for observingclinically significant between-session H-1-MRS changes was evaluated usingthe reliable change index. Reproducibility measures for metabolite peak areas were only moderately concordant with percentage variation ranging from 14% to 20% for NA, Cho, and Cr. Stability was much improved when NA ratios and sum of multiple voxels were considered. Between-session NA/(Cho + Cr) changes greater than 22%, 12%, and 10% in one given participant can be detected with a 90% confidence interval when considered at the single-voxel level, the level of a single hippocampus, or the level of both hippocampi, respectively. Left-right asymmetry indices showed similar and limited inter- hemispheric asymmetry in repeated examination. This study suggests that 1H-MRS reproducibility performance is adequate for the study and monitoring of human hippocampus function when NA ratios and the sum of multiple voxels areconsidered. Individual metabolite peaks and single-voxel measurements havelow reproducibility at 1.5 T and should be used only with clearly established statistical parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:44:54