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Titolo:
Discordance between cerebral oxygen and glucose metabolism, and hemodynamics in a mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode patient
Autore:
Nariai, R; Ohno, K; Ohta, Y; Hirakawa, K; Ishii, I; Senda, M;
Indirizzi:
Tokyo Med & Dent Univ, Brain Med Sci Grad Sch, Neurosurg Sect, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan rad Sch, Neurosurg Sect, Tokyo, Japan Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Tokyo, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan tron Med Ctr, Tokyo, Japan
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 3, volume: 11, anno: 2001,
pagine: 325 - 329
SICI:
1051-2284(200107)11:3<325:DBCOAG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELAS SYNDROME; BLOOD-FLOW; ENCEPHALOPATHY; MYOPATHY; BRAIN; TOMOGRAPHY; SPECT; CT;
Keywords:
mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode; xenon computed tomography; acetazolamide; cerebral blood flow; cerebral oxygen metabolism; cerebral glucose metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nariai, R Tokyo Med & Dent Univ, Dept Brain Med Sci, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 Japan
Citazione:
R. Nariai et al., "Discordance between cerebral oxygen and glucose metabolism, and hemodynamics in a mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode patient", J NEUROIMAG, 11(3), 2001, pp. 325-329

Abstract

A patient with mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode (MELAS) syndrome underwent serial measurement of cerebral blood flow with xenon computed tomography (Xe-CBF) while presenting with strokelike episodes accompanied by a cerebral lesion. He underwent positron emission tomography (PET) measurement of the regional cerebral blood Row (PET-CBF), metabolic rate of oxygen (CMRO2), and glucose (CMRGlu) after his symptoms and lesion disappeared. During the symptomatic period, Xe-CBF and the Xe-CBF response to acetazolamide loading were well preserved both in and outside the low-density lesion. In the PET study, decreased CMRO2 and increased PET-CBF and CMRGlu were noted in the entire brain. The strokelike episodes of patients with MELAS are more likely attributed to the failure of oxygen metabolism than to a vascular accident.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:26:26