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Titolo:
Pharmacokinetics of echocontrast agent infusion in a dog model
Autore:
Kaps, M; Seidel, G; Algermissen, C; Gerriets, T; Broillet, A;
Indirizzi:
Univ Giessen, Med Ctr Neurol & Neurosurg, Dept Neurol, D-35385 Giessen, Germany Univ Giessen Giessen Germany D-35385 pt Neurol, D-35385 Giessen, Germany Med Univ Lubeck, Dept Neurol, Lubeck, Germany Med Univ Lubeck Lubeck Germany niv Lubeck, Dept Neurol, Lubeck, Germany Bracco Res SA, Geneva, Switzerland Bracco Res SA Geneva SwitzerlandBracco Res SA, Geneva, Switzerland
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 3, volume: 11, anno: 2001,
pagine: 298 - 302
SICI:
1051-2284(200107)11:3<298:POEAII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-CIRCULATION; ECHO-CONTRAST;
Keywords:
ultrasonics; contrast agent; transcranial Doppler; cerebral vessels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Kaps, M Univ Giessen, Med Ctr Neurol & Neurosurg, Dept Neurol, Steg 14, D-35385 Giessen, Germany Univ Giessen Steg 14 Giessen Germany D-35385 385 Giessen, Germany
Citazione:
M. Kaps et al., "Pharmacokinetics of echocontrast agent infusion in a dog model", J NEUROIMAG, 11(3), 2001, pp. 298-302

Abstract

Ultrasound contrast agents (UCAs) have a distinct diagnostic impact on transcranial Doppler (TCD) and duplex sonography. In addition to the properties of the UCA and ultrasound imaging modes, the duration of contrast enhancement depends on the administration mode. infusion of UCAs may be appropriate for prolonging the diagnostically useful time of elevated Doppler intensity. Five sedated dogs were investigated by TCD during infusion with SonoVue(TM), a new UCA consisting of sulfur hexafluoride microbubbles. The infusion rate was varied, and the time-intensity curves were analyzed. Infusion rate of 70 ml/h provided a stable mean level of increased Doppler intensity up to 24 to 26 dB over baseline, whereas a rate of 35 ml/h did not result ina stable plateau (range 8-19 dB over baseline [5 minutes after starting time]). The maximum increases in Doppler mean intensity (18.2 dB [35 ml/h] and 25.6 dB [70 ml/h]) were significantly different (P = .025). Pharmacokinetic analysis of SonoVue(TM) during inflow (by exponential functional fittingof the time-mean intensity curves) and elimination (by linear regression analysis) revealed no dose-related differences. This study demonstrated a dose-dependent level of increased Doppler mean intensity within the brain circulation during infusion of SonoVue(TM). Unlike the bell-shaped course of Doppler signal enhancement seen after bolus injection, infusion generates a stable plateau, which is an important prerequisite for more advanced contrast applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:24:23