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Titolo:
H-1 spectroscopy in patients with amyotrophic lateral sclerosis
Autore:
Kenn, W; Ochs, G; Pabst, TA; Hahn, D;
Indirizzi:
Univ Wurzburg, Inst Rontgendiagnost, Dept Radiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Radiol, D-97080 Wurzburg, Germany Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Neurol, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 3, volume: 11, anno: 2001,
pagine: 293 - 297
SICI:
1051-2284(200107)11:3<293:HSIPWA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; MOTOR-NEURON DISEASE; ACETYL-ASPARTYL-GLUTAMATE; AMINO-ACIDS; HUMAN BRAIN; IN-VIVO; PROTON; CORTEX;
Keywords:
H-1 spectroscopy; amyotrophic lateral sclerosis; brain metabolites; chemical shift imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kenn, W Univ Wurzburg, Inst Rontgendiagnost, Dept Radiol, Joseph Schneiderstr 2, D-97080 Wurzburg, Germany Univ Wurzburg Joseph Schneiderstr 2 Wurzburg Germany D-97080 many
Citazione:
W. Kenn et al., "H-1 spectroscopy in patients with amyotrophic lateral sclerosis", J NEUROIMAG, 11(3), 2001, pp. 293-297

Abstract

Background and Purpose. The authors investigate changes in brain metabolites among patients with amyotrophic lateral sclerosis (ALS). Twelve patientsdiagnosed with definite ALS (and 2 subgroups with either pronounced upper motoneuron signs or less obvious, probable upper motoneuron involvement) and 10 controls were examined. H-1 studies were performed on a 1.5-T Siemens Magnetom Vision with single voxel (SV). A voxel (TR = 1500 ms, TE = 270 ms,512 acquisitions, VOI = 8 cm(3)) was placed bilaterally in the precentral gyrus. In addition, chemical shift imaging (CSI) (VOI = 1 x 1 x 1.5 cm, TR = 1500 ms, TE = 135 ms) was performed. Ratios of peak integrals (N-acetyl-aspartate/choline, N-acetyl-aspartate/creatine, and creatine/choline) were determined. A Mann-Whitney U Test and a Wilcoxon Matched Pairs Test were applied. Methods. The statistical analysis failed to demonstrate any significant differences between the ALS patients and the controls with respect to ratio measures. Using CSI, it was found that patients with clinically pronounced upper motoneuron signs had significantly lower (P = .037) N-acetyl-aspartate/choline ratios in the more affected hemisphere. Conclusions. The authors conclude that CSI is more effective at detecting lower N-acetyl-aspartate/choline levels among ALS patients than is SV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:52:09