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Titolo:
Effect of adenosine on cerebral blood flow velocity
Autore:
Zanferrari, C; Razumovsky, AY; Lavados, PM; Sen, S; Oppenheimer, SM;
Indirizzi:
Johns Hopkins Med Inst, Div Neurosci Crit Care, Dept Neurol, Baltimore, MD21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 rol, Baltimore, MD21287 USA Univ Parma, Inst Neurol, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 Parma, Inst Neurol, I-43100 Parma, Italy Alemana Hosp, Dept Neurol Sci, Santiago, Chile Alemana Hosp Santiago Chile mana Hosp, Dept Neurol Sci, Santiago, Chile New Jersey Neurosci Inst, Dept Neurosci, Edison, NJ USA New Jersey Neurosci Inst Edison NJ USA st, Dept Neurosci, Edison, NJ USA
Titolo Testata:
JOURNAL OF NEUROIMAGING
fascicolo: 3, volume: 11, anno: 2001,
pagine: 272 - 279
SICI:
1051-2284(200107)11:3<272:EOAOCB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; TRANSCRANIAL DOPPLER; CEREBROVASCULAR REACTIVITY; VASOMOTOR REACTIVITY; STROKE RISK; ACETAZOLAMIDE; DIPYRIDAMOLE; DISEASE; HUMANS; CO2;
Keywords:
adenosine; ultrasound; cerebrovascular reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Razumovsky, AY Johns Hopkins Med Inst, Div Neurosci Crit Care, Dept Neurol, Meyer 8-140,NWolfe St, Baltimore, MD 21287 USA Johns Hopkins Med Inst Meyer 8-140,N Wolfe St Baltimore MD USA 21287
Citazione:
C. Zanferrari et al., "Effect of adenosine on cerebral blood flow velocity", J NEUROIMAG, 11(3), 2001, pp. 272-279

Abstract

Background and Purpose. Evidence suggests that adenosine (ADN) is a potentvasodilator of cerebral vessels. However, the feasibility of manipulating human cerebral vascular resistance with ADN has not been assessed by means of TCD. The purpose of this study was to quantitatively estimate the changein middle cerebral artery cerebral blood flow velocity (CBFV) in response to intravenous ADN infusion in humans. Methods. Eleven patients with subacute cerebrovascular events (ischemic stroke, transient ischemic attack, or hemorrhage) undergoing adenosine-thallium stress testing were studied before, during, and after ADN infusion to evaluate the effect of ADN on cerebral blood flow velocity. Continuous blood pressure (BP), heart rate (HR), respiration rate (RR), end-tidal CO2 (ET-CO2), and transcranial Doppler ultrasonography monitoring of CBFV and pulsatility index (PI) in both middle cerebral arteries were performed. Results. The mean CBFVs were 65.4 +/- 19.2 cm/sbefore, 55.4 +/- 18.1 cm/s during, and 64.1 +/- 22.5 cm/s after ADN infusion, which represents a statistically significant decrease during ADN test compared with both baseline (P = .007) and posttest levels (P = .017). The PI was increased during the test (0.91 +/- 0.2) when compared with baseline (0.71 +/- 0.1) (P = .007). During ADN injection, mean HR increased (P = .004) and mean ET-CO2 levels decreased significantly (P = .003). Mean BP and RR did not change significantly. Conclusions. The authors hypothesize that any direct vasodilatory effect of ADN on the distal cerebral peripheral vasculature may be negated by an effect of ADN on depth of respiration resulting in hypocapnia and secondary distal vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:58:33