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Titolo:
CSF studies in violent offenders - I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy
Autore:
Soderstrom, H; Blennow, K; Manhem, A; Forsman, A;
Indirizzi:
Univ Gothenburg, Inst Clin Neurosci, Dept Psychiat, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden ci, Dept Psychiat, Gothenburg, Sweden Natl Board Forens Med, Dept Forens Psychiat, Gothenburg, Sweden Natl BoardForens Med Gothenburg Sweden ns Psychiat, Gothenburg, Sweden Univ Gothenburg, Inst Clin Neurosci, Dept Neurol & Neurochem, Molndal, Sweden Univ Gothenburg Molndal Sweden Dept Neurol & Neurochem, Molndal, Sweden Sahlgrens Univ Hosp, Molndal, Sweden Sahlgrens Univ Hosp Molndal SwedenSahlgrens Univ Hosp, Molndal, Sweden
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 7, volume: 108, anno: 2001,
pagine: 869 - 878
SICI:
0300-9564(2001)108:7<869:CSIVO->2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; 5-HYDROXYINDOLEACETIC ACID; MONOAMINE METABOLITES; AGGRESSIVE-BEHAVIOR; SUICIDE; DISORDER;
Keywords:
aggression; violence; psychopathy; serotonin; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Soderstrom, H Dept Forens Psychiat, Box 4024, S-42204 Hisings Backa, Sweden Dept Forens Psychiat Box 4024 Hisings Backa Sweden S-42204
Citazione:
H. Soderstrom et al., "CSF studies in violent offenders - I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy", J NEURAL TR, 108(7), 2001, pp. 869-878

Abstract

Low serotonin activity in man has been related to impulsive, self-destructive violence but not to instrumental aggression aimed at dominance. A relationship has also been suggested between aggression and high catecholaminergic activity. Several studies have reported signs of aberrant dopaminergic function in attention deficit hyperactivity disorder, autism, and schizophrenia. In 22 violent offenders undergoing pretrial forensic psychiatric investigation, interpersonal and behavioral features of psychopathy, measured bythe Psychopathy Checklist Revised (PCL-R), were significantly predicted bylow cerebrospinal fluid (CSF) concentrations of 5-HIAA and high CSF concentrations of HVA in multivariate regression models. CSF concentrations of MHPG did not contribute to the model. This seems to link the outward-directedaggression of psychopathy to serotonergic hypofunctioning and high dopamine turnover, which might account for disinhibition of destructive impulses.

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Documento generato il 04/04/20 alle ore 15:34:18