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Titolo:
Chronic elevation of amyloid precursor protein in the neocortex or hippocampus of marmosets with selective cholinergic lesions
Autore:
Ramirez, MJ; Ridley, RM; Baker, HF; Maclean, CJ; Honer, WG; Francis, PT;
Indirizzi:
Univ London Kings Coll, GKT Sch Biomed Sci, Neurosci Res Ctr, Biochem Neuropharmacol Grp,Dementia Res Lab, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL b, London SE1 1UL, England Univ Cambridge, Dept Psychol, MRC, Comparat Cognit Team, Cambridge, England Univ Cambridge Cambridge England mparat Cognit Team, Cambridge, England Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada sychiat, Vancouver, BC, Canada
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 7, volume: 108, anno: 2001,
pagine: 809 - 826
SICI:
0300-9564(2001)108:7<809:CEOAPP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; ALZHEIMERS-DISEASE; BASAL FOREBRAIN; MESSENGER-RNA; COGNITIVE IMPAIRMENT; CALLITHRIX-JACCHUS; CEREBRAL-CORTEX; VESICLE PROTEIN; INDUCED INJURY; DIAGONAL BAND;
Keywords:
Alzheimer's disease; amyloid precursor protein; cholinergic; ME20.4IgG-saporin; SNAP-25; syntaxin; synaptophysin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Francis, PT Univ London Kings Coll, GKT Sch Biomed Sci, Neurosci Res Ctr, Biochem Neuropharmacol Grp,Dementia Res Lab, Hodgkin Bldg,St Thomas St, London SE1 1UL,England Univ London Kings Coll Hodgkin Bldg,St Thomas St London England SE1 1UL
Citazione:
M.J. Ramirez et al., "Chronic elevation of amyloid precursor protein in the neocortex or hippocampus of marmosets with selective cholinergic lesions", J NEURAL TR, 108(7), 2001, pp. 809-826

Abstract

In vitro studies have consistently demonstrated a link between cholinergicne uro transmission and amyloid precursor protein metabolism, although fewstudies have examined such a relationship in vivo and none have been conducted in primate species. The purpose of this study was to test the hypothesis that a reduction in cholinergic activity in neocortical and hippocampal areas consequent upon destruction of ascending cholinergic projections may lead to long-term changes in levels of amyloid precursor protein in these target areas in a primate species. The status of three synaptic proteins associated with neurotransmitter release, synaptophysin, syntaxin and SNAP-25,was also been examined. Selective immunolesions of the basal forebrain cholinergic projections led to increases in amyloid precursor protein-like immunoreactivity in hippocampus and cortex, measured 8 months postlesion. Furthermore, reductions in cortical and hippocampal SNAP-25, but not syntaxin or synaptophysin, immunoreactivity were observed. These results imply that the reduced cholinergic activity characteristic of Alzheimer's disease may contribute to the continuing emergence of neuropathology in addition to the well-known association with cognitive dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:46:19