Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Above and within the genome: Epigenetics past and present
Autore:
Urnov, FD; Wolffe, AP;
Indirizzi:
Sangamo Biosci, Pt Richmond Tech Ctr, Richmond, CA 94804 USA Sangamo Biosci Richmond CA USA 94804 ond Tech Ctr, Richmond, CA 94804 USA
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 2, volume: 6, anno: 2001,
pagine: 153 - 167
SICI:
1083-3021(200104)6:2<153:AAWTGE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA METHYLTRANSFERASE GENE; ISLAND METHYLATOR PHENOTYPE; X-CHROMOSOME INACTIVATION; CPG-BINDING PROTEIN-2; HISTONE DEACETYLASE; TRANSCRIPTIONAL REPRESSION; MAMMALIAN DEVELOPMENT; RETT-SYNDROME; CELL-CYCLE; IMMUNODEFICIENCY SYNDROME;
Keywords:
transcription; DNA replication; DNA methylation; MBD; chromatin remodeling; histone modification; histone deacetylase; histone acetyltransferase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Urnov, FD Sangamo Biosci, Pt Richmond Tech Ctr, 501 Canal Blvd,Suite A100,Richmond,CA 94804 USA Sangamo Biosci 501 Canal Blvd,Suite A100 Richmond CAUSA 94804 A
Citazione:
F.D. Urnov e A.P. Wolffe, "Above and within the genome: Epigenetics past and present", J MAMMARY G, 6(2), 2001, pp. 153-167

Abstract

Epigenetic regulation involves the maintenance of a particular state of gene expression-most commonly, repression-in the face of repeated mitosis, and frequently meiosis. Remarkably, changes in such heritable expression states occur without an alteration of the primary DNA sequence. We present a brief history of research in epigenetics, beginning with pioneering work in the 1950s by B. McClintock and R. A. Brink on maize kernel color inheritance. We describe the complex biochemistry of DNA methylation-the molecular basis of most epigenetic regulation in mammalian genomes-and review data connecting it to targeted modification and remodeling of chromatin structure. Several prominent examples of epigenetically regulated loci-X chromosome inactivation, imprinting, repetitive DNA silencing, and aberrant methylation patterns in neoplasia-are reviewed along with a description of our current understanding of the underlying molecular mechanisms. A common theme that emerges is the complex integration of epigenetic regulatory pathways with the chromatin infrastructure over target DNA loci.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:59:34