Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Capillary zone electrophoresis analysis of anti-epileptic drugs
Autore:
Luis, ML; Blanco, D; Arias, JJ; Jimenez, F; Jimenez, A; Fraga, JMG;
Indirizzi:
Univ La Laguna, Dept Quim Analit Nutr & Bromatol, Tenerife 38071, Spain Univ La Laguna Tenerife Spain 38071 tr & Bromatol, Tenerife 38071, Spain Univ Oviedo, Fac Quim, Dept Quim Fis & Analit, E-33006 Oviedo, Asturias, Spain Univ Oviedo Oviedo Asturias Spain E-33006 E-33006 Oviedo, Asturias, Spain
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 13, volume: 24, anno: 2001,
pagine: 1921 - 1928
SICI:
1082-6076(2001)24:13<1921:CZEAOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ANTIEPILEPTIC DRUGS; HUMAN PLASMA; PHENYTOIN; SERUM; IMMUNOASSAY; METABOLITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Arias, JJ Univ La Laguna, Dept Quim Analit Nutr & Bromatol, Tenerife 38071, Spain Univ La Laguna Tenerife Spain 38071 tol, Tenerife 38071, Spain
Citazione:
M.L. Luis et al., "Capillary zone electrophoresis analysis of anti-epileptic drugs", J LIQ CHR R, 24(13), 2001, pp. 1921-1928

Abstract

This paper describes the development of a simple, reliable, reproducible, and fast method, based on capillary zone electrophoresis with diode array detection, for the separation and determination of two antiepileptic drugs. Phenytoin (DPH) and phenobarbital (PB) were separated in 4 min by using a carrier containing glycine 50 mM, pH 10.5. The limit of detection was 0.1 igmL(-1) for both compounds. Satisfactory reproducibility was obtained for migration times (<1.4%) and corrected peak areas (<6.9%) in the analysis of pharmaceutical formulations. The average recoveries obtained, which ranged between 100 and 108%, testify to the accuracy of the proposed method.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:48:26